Balancing gene transfection and cytotoxicity of nucleic acid carriers with focus on ocular and hepatic disorders: evaluation of hydrophobic and hydrophilic polyethyleneimine derivatives

Polyethyleneimine (PEI) derivatives substituted by lactose, succinic acid or alkyl domains were evaluated as nonviral gene delivery vectors towards balancing gene transfection and cytotoxicity. The investigations were focused on pDNA transfection into arising retinal pigment epithelia (ARPE-19) and...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2023-05, Vol.11 (2), p.4556-4571
Hauptverfasser:	de Oliveira, Fernando A, Albuquerque, Lindomar J. C, Nascimento-Sales, Michelle, Christoffolete, Marcelo A, Bellettini, Ismael C, Giacomelli, Fernando C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Balancing Cytotoxicity Deoxyribonucleic acid Disorders DNA DNA - chemistry DNA - genetics Domains Eye disorders Galactose Gene therapy Gene transfer Hepatocellular carcinoma Humans Hydrophilicity Hydrophobicity Lactose Liver Liver Neoplasms - genetics Molecular chains Nucleic Acids Plasmids Polyethyleneimine Polyethyleneimine - chemistry Polymers Protein adsorption Succinic Acid Toxicity Transfection Tumor cell lines
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