A STUDY ON THE EFFECT OF (2R)-4'-O-TETRAHYDROPYRANYLADRIAMYCIN, A NEW ANTITUMOR ANTIBIOTIC, ON REPRODUCTION: II. ITS TERATOGENICITY IN RATS AND RABBITS

This paper describes the embryotoxicity and teratogenic effects of (2R)-4'-O-Tetrahydropyranyladriamycin (THP). The drug was administered intravenously to female rats at 0.01, 0.03, 0.1 or 0.3mg/kg daily from day 7 to day 17 of pregnancy and to female rabbits at 0.01, 0.05 or 0.1mg/kg daily fro...

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Veröffentlicht in:	Japanese journal of antibiotics 1986/02/25, Vol.39(2), pp.477-506
Hauptverfasser:	KUREBE, MASARU, ASAOKA, HIROYASU, MORIGUCHI, MASAHIDE, HATA, TOSHIAKI, OKANO, KAZUO, ITO, MINAKO
Format:	Artikel
Sprache:	jpn
Schlagworte:	Abnormalities, Drug-Induced Animals Animals, Newborn - growth & development Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - toxicity Body Weight - drug effects Doxorubicin - administration & dosage Doxorubicin - analogs & derivatives Doxorubicin - toxicity Drinking - drug effects Eating - drug effects Embryonic and Fetal Development - drug effects Female Fetus - drug effects Injections, Intravenous Male Organ Size - drug effects Pregnancy Rabbits Rats Rats, Inbred Strains Reproduction - drug effects
Online-Zugang:	Volltext
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