Diplacone Isolated from Paulownia tomentosa Mature Fruit Induces Ferroptosis-Mediated Cell Death through Mitochondrial Ca 2+ Influx and Mitochondrial Permeability Transition

The recently defined type of cell death ferroptosis has garnered significant attention as a potential new approach to cancer treatment owing to its more immunogenic nature when compared with apoptosis. Ferroptosis is characterized by the depletion of glutathione (GSH)/glutathione peroxidase-4 (GPx4)...

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Veröffentlicht in:	International journal of molecular sciences 2023-04, Vol.24 (8)
Hauptverfasser:	Oh, Eun Sol, Ryu, Hyung Won, Song, Yu Na, Kang, Myung-Ji, Huh, Yang Hoon, Park, Ji-Yoon, Oh, Seon Min, Lee, Su-Yeon, Park, Yhun Jung, Kim, Doo-Young, Ro, Hyunju, Hong, Sung-Tae, Lee, Su Ui, Moon, Dong-Oh, Kim, Mun-Ock
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Death - physiology Ferroptosis Fruit - metabolism Glutathione - metabolism Humans Lipid Peroxidation Mitochondrial Permeability Transition Pore - metabolism Mitochondrial Transmembrane Permeability-Driven Necrosis Reactive Oxygen Species - metabolism
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