Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of T H 9 cells to promote allergic inflammation

Allergic diseases are a major global health issue. Interleukin (IL)-9-producing helper T (T 9) cells promote allergic inflammation, yet T 9 cell effector functions are incompletely understood because their lineage instability makes them challenging to study. Here we found that resting T 9 cells prod...

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Veröffentlicht in:	Nature immunology 2023-06, Vol.24 (6), p.1036
Hauptverfasser:	Son, Aran, Meylan, Francoise, Gomez-Rodriguez, Julio, Kaul, Zenia, Sylvester, McKella, Falduto, Guido H, Vazquez, Estefania, Haque, Tamara, Kitakule, Moses M, Wang, Chujun, Manthiram, Kalpana, Qi, Chen-Feng, Cheng, Jun, Gurram, Rama K, Zhu, Jinfang, Schwartzberg, Pamela, Milner, Joshua D, Frischmeyer-Guerrerio, Pamela A, Schwartz, Daniella M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation Chromatin - genetics Humans Hypersensitivity - genetics Inflammation Interleukin-9 - genetics Janus Kinase Inhibitors STAT5 Transcription Factor - genetics STAT6 Transcription Factor T-Lymphocytes, Helper-Inducer
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