Ca 2+ -Permeable TRPV1 Receptor Mediates Neuroprotective Effects in a Mouse Model of Alzheimer's Disease via BDNF/CREB Signaling Pathway

Transient receptor potential vanilloid 1 (TRPV1) protein is a Ca -permeable non-selective cation channel known for its pain modulation pathway. In a previous study, it was discovered that a triple-transgenic Alzheimer's disease (AD) mouse model (3xTg-AD ) has anti-AD effects. The expression of...

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Veröffentlicht in:	Molecules and cells 2023-05, Vol.46 (5), p.319
Hauptverfasser:	Kim, Juyong, Seo, Sangwoo, Park, Jung Han Yoon, Lee, Ki Won, Kim, Jiyoung, Kim, Jin-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Animals Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - pharmacology Cyclic AMP Response Element-Binding Protein - metabolism Disease Models, Animal Hippocampus Mice Mice, Transgenic Neuroprotective Agents - pharmacology Proto-Oncogene Proteins c-bcl-2 - metabolism Signal Transduction TRPV Cation Channels - genetics TRPV Cation Channels - metabolism TRPV Cation Channels - pharmacology
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