Cobalt induces neurodegeneration through FTO-triggered autophagy impairment by targeting TSC1 in an m 6 A-YTHDF2-dependent manner

Cobalt is the most widely used heavy metal pollutant in medicine and industry. Excessive cobalt exposure can adversely affect human health. Neurodegenerative symptoms have been observed in cobalt-exposed populations; however, the underlying mechanisms remain largely unknown. In this study, we demons...

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Veröffentlicht in:	Journal of hazardous materials 2023-07, Vol.453, p.131354
Hauptverfasser:	Tang, Jianping, Zheng, Fuli, Liu, Xu, Li, Yanjun, Guo, Zhenkun, Lin, Xinpei, Zhou, Jinfu, Zhang, Yu, Yu, Guangxia, Hu, Hong, Shao, Wenya, Wu, Siying, Li, Huangyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism Animals Autophagy Cobalt - toxicity Humans Mice Obesity RNA-Binding Proteins - metabolism Signal Transduction Transcription Factors - metabolism
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