Bladder Training and Terodiline in Females with Idiopathic Urge Incontinence and Stable Detrusor Function
Twenty consecutive female patients with urge incontinence and stable detrusor function on provocative rapid fill CO2-cystometry were treated as out-patients with a bladder training programme and with terodiline/placebo in a double-blind cross-over design. Frequency and incontinence episodes decrease...
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| Veröffentlicht in: | Scandinavian journal of urology and nephrology 1986, Vol.20 (1), p.41-46 |
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| container_end_page | 46 |
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| container_title | Scandinavian journal of urology and nephrology |
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| creator | Klarskov, Peter Gerstenberg, Thomas C. Hald, Tage |
| description | Twenty consecutive female patients with urge incontinence and stable detrusor function on provocative rapid fill CO2-cystometry were treated as out-patients with a bladder training programme and with terodiline/placebo in a double-blind cross-over design. Frequency and incontinence episodes decreased significantly, while first sensation and cystometric bladder capacity increased. Both objectively and subjectively terodiline was significantly better than placebo with 50% (95% confidence limits 18-82) more patients improved on terodiline than on placebo. Thirty percent of the patients (95 % confidence limits 12-54) relapsed after withdrawal of terodiline. At 3 months follow-up the remaining 70% were satisfied with the outcome of the training programme. Side effects were mild and reversible. Serum creatinine and alkaline phosphatase increased slightly on terodiline and the diastolic blood pressure was probably also increased by terodiline. In conclusion, female patients with idiopathic urge incontinence and stable detrusor function did respond to treatment as do female patients with urge incontinence and proven instability |
| doi_str_mv | 10.3109/00365598609024478 |
| format | Article |
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Frequency and incontinence episodes decreased significantly, while first sensation and cystometric bladder capacity increased. Both objectively and subjectively terodiline was significantly better than placebo with 50% (95% confidence limits 18-82) more patients improved on terodiline than on placebo. Thirty percent of the patients (95 % confidence limits 12-54) relapsed after withdrawal of terodiline. At 3 months follow-up the remaining 70% were satisfied with the outcome of the training programme. Side effects were mild and reversible. Serum creatinine and alkaline phosphatase increased slightly on terodiline and the diastolic blood pressure was probably also increased by terodiline. In conclusion, female patients with idiopathic urge incontinence and stable detrusor function did respond to treatment as do female patients with urge incontinence and proven instability</description><identifier>ISSN: 0036-5599</identifier><identifier>EISSN: 1651-2065</identifier><identifier>DOI: 10.3109/00365598609024478</identifier><identifier>PMID: 3704568</identifier><identifier>CODEN: SJUNAS</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Butylamines - adverse effects ; Butylamines - therapeutic use ; Calcium Channel Blockers - adverse effects ; Calcium Channel Blockers - therapeutic use ; Female ; Humans ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Urinary Bladder - physiopathology ; Urinary Incontinence - drug therapy ; Urinary Incontinence - physiopathology ; Urinary Incontinence - therapy ; Urinary system</subject><ispartof>Scandinavian journal of urology and nephrology, 1986, Vol.20 (1), p.41-46</ispartof><rights>1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1986</rights><rights>1987 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-b8fb36fc74b15cc57399b24fe210cec6ae9ca8b58474b4ae8a0da80501ce420d3</citedby><cites>FETCH-LOGICAL-c430t-b8fb36fc74b15cc57399b24fe210cec6ae9ca8b58474b4ae8a0da80501ce420d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365598609024478$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365598609024478$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7902177$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3704568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klarskov, Peter</creatorcontrib><creatorcontrib>Gerstenberg, Thomas C.</creatorcontrib><creatorcontrib>Hald, Tage</creatorcontrib><title>Bladder Training and Terodiline in Females with Idiopathic Urge Incontinence and Stable Detrusor Function</title><title>Scandinavian journal of urology and nephrology</title><addtitle>Scand J Urol Nephrol</addtitle><description>Twenty consecutive female patients with urge incontinence and stable detrusor function on provocative rapid fill CO2-cystometry were treated as out-patients with a bladder training programme and with terodiline/placebo in a double-blind cross-over design. Frequency and incontinence episodes decreased significantly, while first sensation and cystometric bladder capacity increased. Both objectively and subjectively terodiline was significantly better than placebo with 50% (95% confidence limits 18-82) more patients improved on terodiline than on placebo. Thirty percent of the patients (95 % confidence limits 12-54) relapsed after withdrawal of terodiline. At 3 months follow-up the remaining 70% were satisfied with the outcome of the training programme. Side effects were mild and reversible. Serum creatinine and alkaline phosphatase increased slightly on terodiline and the diastolic blood pressure was probably also increased by terodiline. In conclusion, female patients with idiopathic urge incontinence and stable detrusor function did respond to treatment as do female patients with urge incontinence and proven instability</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Butylamines - adverse effects</subject><subject>Butylamines - therapeutic use</subject><subject>Calcium Channel Blockers - adverse effects</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Urinary Bladder - physiopathology</subject><subject>Urinary Incontinence - drug therapy</subject><subject>Urinary Incontinence - physiopathology</subject><subject>Urinary Incontinence - therapy</subject><subject>Urinary system</subject><issn>0036-5599</issn><issn>1651-2065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EKtvCA3BA8oFrYJzYTiK40MLSlSpxYHuOJvak68prr2yvqr49KbuthCr1NIf_-0YzP2MfBHxuBPRfABqtVN9p6KGWsu1esYXQSlQ1aPWaLR7yagb6t-w051sAqLXQJ-ykaUEq3S2YO_doLSW-TuiCCzccg-VrStE67wJxF_iStugp8ztXNnxlXdxh2TjDr9MN8VUwMZSZDIb-uX8Kjp74Dyppn2Piy30wxcXwjr2Z0Gd6f5xn7Hr5c31xWV39_rW6-H5VGdlAqcZuGhs9mVaOQhmj2qbvx1pOVAswZDRSb7AbVSdnQiJ1CBY7UCAMyRpsc8bEYa9JMedE07BLbovpfhAwPLQ2PGttdj4enN1-3JJ9Mo41zfmnY47ZoJ8SBuPyE9bOe0Tbzti3A-bCFNMW72Lydih472N6dJqXrvj6n74h9GVjMNFwG_cpzK298MNf0JKa9w</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Klarskov, Peter</creator><creator>Gerstenberg, Thomas C.</creator><creator>Hald, Tage</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1986</creationdate><title>Bladder Training and Terodiline in Females with Idiopathic Urge Incontinence and Stable Detrusor Function</title><author>Klarskov, Peter ; Gerstenberg, Thomas C. ; Hald, Tage</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-b8fb36fc74b15cc57399b24fe210cec6ae9ca8b58474b4ae8a0da80501ce420d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Butylamines - adverse effects</topic><topic>Butylamines - therapeutic use</topic><topic>Calcium Channel Blockers - adverse effects</topic><topic>Calcium Channel Blockers - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Urinary Bladder - physiopathology</topic><topic>Urinary Incontinence - drug therapy</topic><topic>Urinary Incontinence - physiopathology</topic><topic>Urinary Incontinence - therapy</topic><topic>Urinary system</topic><toplevel>online_resources</toplevel><creatorcontrib>Klarskov, Peter</creatorcontrib><creatorcontrib>Gerstenberg, Thomas C.</creatorcontrib><creatorcontrib>Hald, Tage</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Scandinavian journal of urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klarskov, Peter</au><au>Gerstenberg, Thomas C.</au><au>Hald, Tage</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bladder Training and Terodiline in Females with Idiopathic Urge Incontinence and Stable Detrusor Function</atitle><jtitle>Scandinavian journal of urology and nephrology</jtitle><addtitle>Scand J Urol Nephrol</addtitle><date>1986</date><risdate>1986</risdate><volume>20</volume><issue>1</issue><spage>41</spage><epage>46</epage><pages>41-46</pages><issn>0036-5599</issn><eissn>1651-2065</eissn><coden>SJUNAS</coden><abstract>Twenty consecutive female patients with urge incontinence and stable detrusor function on provocative rapid fill CO2-cystometry were treated as out-patients with a bladder training programme and with terodiline/placebo in a double-blind cross-over design. Frequency and incontinence episodes decreased significantly, while first sensation and cystometric bladder capacity increased. Both objectively and subjectively terodiline was significantly better than placebo with 50% (95% confidence limits 18-82) more patients improved on terodiline than on placebo. Thirty percent of the patients (95 % confidence limits 12-54) relapsed after withdrawal of terodiline. At 3 months follow-up the remaining 70% were satisfied with the outcome of the training programme. Side effects were mild and reversible. Serum creatinine and alkaline phosphatase increased slightly on terodiline and the diastolic blood pressure was probably also increased by terodiline. In conclusion, female patients with idiopathic urge incontinence and stable detrusor function did respond to treatment as do female patients with urge incontinence and proven instability</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>3704568</pmid><doi>10.3109/00365598609024478</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-5599 |
| ispartof | Scandinavian journal of urology and nephrology, 1986, Vol.20 (1), p.41-46 |
| issn | 0036-5599 1651-2065 |
| language | eng |
| recordid | cdi_pubmed_primary_3704568 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Aged Biological and medical sciences Butylamines - adverse effects Butylamines - therapeutic use Calcium Channel Blockers - adverse effects Calcium Channel Blockers - therapeutic use Female Humans Medical sciences Middle Aged Pharmacology. Drug treatments Urinary Bladder - physiopathology Urinary Incontinence - drug therapy Urinary Incontinence - physiopathology Urinary Incontinence - therapy Urinary system |
| title | Bladder Training and Terodiline in Females with Idiopathic Urge Incontinence and Stable Detrusor Function |
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