GSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload

Gasdermin D (GSDMD) forms membrane pores to execute pyroptosis. But the mechanism of how cardiomyocyte pyroptosis induces cardiac remodeling in pressure overload remains unclear. We investigated the role of GSDMD-mediated pyroptosis in the pathogenesis of cardiac remodeling in pressure overload. Wil...

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Veröffentlicht in:	Clinical and experimental hypertension (1993) 2023-12, Vol.45 (1), p.2189138-2189138
Hauptverfasser:	You, Jieyun, Li, Xuan, Dai, Fangjie, Liu, Jun, Zhang, Qi, Guo, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cardiac remodeling Cardiomegaly - metabolism Fibrosis Gasdermin D (GSDMD) Gasdermins - metabolism Humans Hypertension - complications Interleukin-18 - metabolism Mice Mice, Inbred C57BL Myocytes, Cardiac - metabolism pressure overload Pyroptosis transverse aortic constriction (TAC) Ventricular Remodeling
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