Biotransformation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, in rat liver microsomes
1. The metabolism of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, was investigated in vitro using fortified rat liver microsomal preparations. 2. Two metabolic products, N-desmethyl stobadine and stobadine N-oxide were isolated and identified by means of t.l.c., g.l.c.-mass sp...
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| Veröffentlicht in: | Xenobiotica 1987, Vol.17 (9), p.1067-1073 |
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| container_issue | 9 |
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| container_title | Xenobiotica |
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| creator | ktefek, M. Bene k, L. Jergelová, M. k Kasnár, V. Turi-nagy, L. Ko ki k, P. |
| description | 1. The metabolism of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, was investigated in vitro using fortified rat liver microsomal preparations.
2. Two metabolic products, N-desmethyl stobadine and stobadine N-oxide were isolated and identified by means of t.l.c., g.l.c.-mass spectrometry, n.m.r. spectrometry and comparison with synthetic reference compounds.
3. Stobadine N-oxide was resolved into two optically active stereoisomers which were produced enzymically in approximately equal quantities. |
| doi_str_mv | 10.3109/00498258709044205 |
| format | Article |
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2. Two metabolic products, N-desmethyl stobadine and stobadine N-oxide were isolated and identified by means of t.l.c., g.l.c.-mass spectrometry, n.m.r. spectrometry and comparison with synthetic reference compounds.
3. Stobadine N-oxide was resolved into two optically active stereoisomers which were produced enzymically in approximately equal quantities.</description><identifier>ISSN: 0049-8254</identifier><identifier>EISSN: 1366-5928</identifier><identifier>DOI: 10.3109/00498258709044205</identifier><identifier>PMID: 3687063</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Anti-Arrhythmia Agents - pharmacokinetics ; Biotransformation ; Carbolines - pharmacokinetics ; Cardiotonic Agents - pharmacokinetics ; Chromatography, Gas ; Chromatography, Thin Layer ; Gas Chromatography-Mass Spectrometry ; In Vitro Techniques ; Magnetic Resonance Spectroscopy ; Male ; Microsomes, Liver - metabolism ; Rats ; Rats, Inbred Strains</subject><ispartof>Xenobiotica, 1987, Vol.17 (9), p.1067-1073</ispartof><rights>1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-41700f0f1bb457edb3c695972cb73dec71f8d5e2a2da6ab94373bd6377c312d73</citedby><cites>FETCH-LOGICAL-c401t-41700f0f1bb457edb3c695972cb73dec71f8d5e2a2da6ab94373bd6377c312d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00498258709044205$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00498258709044205$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4021,27921,27922,27923,59645,59751,60434,60540,61219,61254,61400,61435</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3687063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ktefek, M.</creatorcontrib><creatorcontrib>Bene k, L.</creatorcontrib><creatorcontrib>Jergelová, M.</creatorcontrib><creatorcontrib>k Kasnár, V.</creatorcontrib><creatorcontrib>Turi-nagy, L.</creatorcontrib><creatorcontrib>Ko ki k, P.</creatorcontrib><title>Biotransformation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, in rat liver microsomes</title><title>Xenobiotica</title><addtitle>Xenobiotica</addtitle><description>1. The metabolism of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, was investigated in vitro using fortified rat liver microsomal preparations.
2. Two metabolic products, N-desmethyl stobadine and stobadine N-oxide were isolated and identified by means of t.l.c., g.l.c.-mass spectrometry, n.m.r. spectrometry and comparison with synthetic reference compounds.
3. Stobadine N-oxide was resolved into two optically active stereoisomers which were produced enzymically in approximately equal quantities.</description><subject>Animals</subject><subject>Anti-Arrhythmia Agents - pharmacokinetics</subject><subject>Biotransformation</subject><subject>Carbolines - pharmacokinetics</subject><subject>Cardiotonic Agents - pharmacokinetics</subject><subject>Chromatography, Gas</subject><subject>Chromatography, Thin Layer</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>In Vitro Techniques</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Microsomes, Liver - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0049-8254</issn><issn>1366-5928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKHTEcxoNY9PS0D-BCyMqV0-Y2yQy6sdIbCN3U9ZDbOJGZ5JhkLOe5-h59pmY8B0GkXYV_vgsfPwBOMPpAMWo_IsTahtSNQC1ijKD6AKww5byqW9IcgtWiV8XAjsHblO4RQhwTcgSOKC8ZTlfg4ZMLOUqf-hAnmV3wMPQw5aCkcd6eQwn__K60jCqM5YbSZydjHLZ5mJwup4FFNC5sYshWZ_dYPHfW53PoPIwyw7F8RVjMMaQw2fQOvOnlmOz7_bsGt18-_7z-Vt38-Pr9-uqm0gzhXDEsEOpRj5VitbBGUc3buhVEK0GN1QL3jaktkcRILlXLqKDKcCqEppgYQdfgbNdblj3MNuVucknbcZTehjl1QjSMY9YUI94Zl4Up2r7bRDfJuO0w6hbM3SvMJXO6L5_VZM1zYs-16Jc73fknsL9CHE2X5XYMsS-4tUtL9b_rL17EByvHPBTQtrsPc_SF23_G_QUNT6AO</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>ktefek, M.</creator><creator>Bene k, L.</creator><creator>Jergelová, M.</creator><creator>k Kasnár, V.</creator><creator>Turi-nagy, L.</creator><creator>Ko ki k, P.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Biotransformation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, in rat liver microsomes</title><author>ktefek, M. ; Bene k, L. ; Jergelová, M. ; k Kasnár, V. ; Turi-nagy, L. ; Ko ki k, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-41700f0f1bb457edb3c695972cb73dec71f8d5e2a2da6ab94373bd6377c312d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Anti-Arrhythmia Agents - pharmacokinetics</topic><topic>Biotransformation</topic><topic>Carbolines - pharmacokinetics</topic><topic>Cardiotonic Agents - pharmacokinetics</topic><topic>Chromatography, Gas</topic><topic>Chromatography, Thin Layer</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>In Vitro Techniques</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Microsomes, Liver - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ktefek, M.</creatorcontrib><creatorcontrib>Bene k, L.</creatorcontrib><creatorcontrib>Jergelová, M.</creatorcontrib><creatorcontrib>k Kasnár, V.</creatorcontrib><creatorcontrib>Turi-nagy, L.</creatorcontrib><creatorcontrib>Ko ki k, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Xenobiotica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ktefek, M.</au><au>Bene k, L.</au><au>Jergelová, M.</au><au>k Kasnár, V.</au><au>Turi-nagy, L.</au><au>Ko ki k, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biotransformation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, in rat liver microsomes</atitle><jtitle>Xenobiotica</jtitle><addtitle>Xenobiotica</addtitle><date>1987</date><risdate>1987</risdate><volume>17</volume><issue>9</issue><spage>1067</spage><epage>1073</epage><pages>1067-1073</pages><issn>0049-8254</issn><eissn>1366-5928</eissn><abstract>1. The metabolism of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, was investigated in vitro using fortified rat liver microsomal preparations.
2. Two metabolic products, N-desmethyl stobadine and stobadine N-oxide were isolated and identified by means of t.l.c., g.l.c.-mass spectrometry, n.m.r. spectrometry and comparison with synthetic reference compounds.
3. Stobadine N-oxide was resolved into two optically active stereoisomers which were produced enzymically in approximately equal quantities.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>3687063</pmid><doi>10.3109/00498258709044205</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-8254 |
| ispartof | Xenobiotica, 1987, Vol.17 (9), p.1067-1073 |
| issn | 0049-8254 1366-5928 |
| language | eng |
| recordid | cdi_pubmed_primary_3687063 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Anti-Arrhythmia Agents - pharmacokinetics Biotransformation Carbolines - pharmacokinetics Cardiotonic Agents - pharmacokinetics Chromatography, Gas Chromatography, Thin Layer Gas Chromatography-Mass Spectrometry In Vitro Techniques Magnetic Resonance Spectroscopy Male Microsomes, Liver - metabolism Rats Rats, Inbred Strains |
| title | Biotransformation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, in rat liver microsomes |
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