Salmonella effector SopF regulates PANoptosis of intestinal epithelial cells to aggravate systemic infection

SopF, a newly discovered effector secreted by Salmonella pathogenicity island-1 type III secretion system (T3SS1), was reported to target phosphoinositide on host cell membrane and aggravate systemic infection, while its functional relevance and underlying mechanisms have yet to be elucidated. PANop...

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Veröffentlicht in:	Gut microbes 2023-12, Vol.15 (1), p.2180315-2180315
Hauptverfasser:	Yuan, Haibo, Zhou, Liting, Chen, Yilin, You, Jiayi, Hu, Hongye, Li, Yuanyuan, Huang, Rui, Wu, Shuyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - metabolism Caspase 8 - metabolism Caspase-8 Epithelial Cells - metabolism Gastrointestinal Microbiome intestinal epithelial cells Mice PANoptosis PDK1-RSK Phosphatidylinositols - metabolism Protein Kinases - genetics Protein Kinases - metabolism Research Paper Salmonella effector SopF Salmonella typhimurium - metabolism
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