Study on co-delivery of pemetrexed disodium and Bcl-2 siRNA by poly-γ-glutamic acid-modified cationic liposomes for the inhibition of NSCLC

Due to the complexity of the pathophysiology of non-small cell lung cancer (NSCLC) and the susceptibility of single chemotherapy to drug resistance, the combination of drugs and small interfering RNA (siRNA) may produce a desired therapeutic effect on NSCLC through the action of multiple pathways. W...

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Veröffentlicht in:	Drug development and industrial pharmacy 2023-01, Vol.49 (1), p.62-74
Hauptverfasser:	Huang, Xiaoyu, Song, Ruonan, Wang, Xiao, He, Kongfang, Shan, Rumeng, Xie, Fei, Huang, Guihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Non-Small-Cell Lung - drug therapy cationic liposomes Cell Line, Tumor co-delivery Glutamic Acid - therapeutic use Liposomes Lung Neoplasms - drug therapy Mice Non-small cell lung cancer Pemetrexed - pharmacology pemetrexed disodium RNA, Small Interfering small interfering RNA
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