Preparation of pH-sensitive chitosan-deoxycholic acid-sodium alginate nanoparticles loaded with ginsenoside Rb 1 and its controlled release mechanism
Ginsenoside is a natural extract of the genus ginseng, which has tumor preventive and inhibiting effects. In this study, ginsenoside loaded nanoparticles were prepared by an ionic cross-linking method with sodium alginate to enable a sustained slow release effect of ginsenoside Rb in the intestinal...
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| Veröffentlicht in: | International journal of biological macromolecules 2023-04, Vol.234, p.123736 |
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| creator | Dong, Yujia He, Yanhui Fan, Daidi Wu, Zhansheng |
| description | Ginsenoside is a natural extract of the genus ginseng, which has tumor preventive and inhibiting effects. In this study, ginsenoside loaded nanoparticles were prepared by an ionic cross-linking method with sodium alginate to enable a sustained slow release effect of ginsenoside Rb
in the intestinal fluid through an intelligent response. Chitosan grafted hydrophobic group deoxycholic acid was used to synthesize CS-DA, providing loading space for hydrophobic Rb
. Scanning electron microscopy (SEM) showed that the nanoparticles was spherical with smooth surfaces. The encapsulation rate of Rb
enhanced with the increase of sodium alginate concentration and could reach to 76.62 ± 1.78 % when concentration was 3.6 mg/mL. It was found that the release process of CDA-NPs was most consistent with the primary kinetic model which is a diffusion-controlled release mechanism. CDA-NPs exhibited good pH sensitivity and controlled release properties in buffer solutions of different pH's at 1.2 and 6.8. The cumulative release of Rb
from CDA-NPs in simulated gastric fluid was |
| format | Article |
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in the intestinal fluid through an intelligent response. Chitosan grafted hydrophobic group deoxycholic acid was used to synthesize CS-DA, providing loading space for hydrophobic Rb
. Scanning electron microscopy (SEM) showed that the nanoparticles was spherical with smooth surfaces. The encapsulation rate of Rb
enhanced with the increase of sodium alginate concentration and could reach to 76.62 ± 1.78 % when concentration was 3.6 mg/mL. It was found that the release process of CDA-NPs was most consistent with the primary kinetic model which is a diffusion-controlled release mechanism. CDA-NPs exhibited good pH sensitivity and controlled release properties in buffer solutions of different pH's at 1.2 and 6.8. The cumulative release of Rb
from CDA-NPs in simulated gastric fluid was <20 % within 2 h, while could release completely around 24 h in the simulated gastrointestinal fluid release system. It was demonstrated that CDA
-NPs can effectively control release and intelligently deliver ginsenoside Rb
, which is a promising alternative way for oral delivery.</description><identifier>EISSN: 1879-0003</identifier><identifier>PMID: 36801309</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Alginates - chemistry ; Chitosan - chemistry ; Delayed-Action Preparations - chemistry ; Deoxycholic Acid ; Drug Carriers - chemistry ; Ginsenosides ; Hydrogen-Ion Concentration ; Nanoparticles - chemistry</subject><ispartof>International journal of biological macromolecules, 2023-04, Vol.234, p.123736</ispartof><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36801309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Yujia</creatorcontrib><creatorcontrib>He, Yanhui</creatorcontrib><creatorcontrib>Fan, Daidi</creatorcontrib><creatorcontrib>Wu, Zhansheng</creatorcontrib><title>Preparation of pH-sensitive chitosan-deoxycholic acid-sodium alginate nanoparticles loaded with ginsenoside Rb 1 and its controlled release mechanism</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>Ginsenoside is a natural extract of the genus ginseng, which has tumor preventive and inhibiting effects. In this study, ginsenoside loaded nanoparticles were prepared by an ionic cross-linking method with sodium alginate to enable a sustained slow release effect of ginsenoside Rb
in the intestinal fluid through an intelligent response. Chitosan grafted hydrophobic group deoxycholic acid was used to synthesize CS-DA, providing loading space for hydrophobic Rb
. Scanning electron microscopy (SEM) showed that the nanoparticles was spherical with smooth surfaces. The encapsulation rate of Rb
enhanced with the increase of sodium alginate concentration and could reach to 76.62 ± 1.78 % when concentration was 3.6 mg/mL. It was found that the release process of CDA-NPs was most consistent with the primary kinetic model which is a diffusion-controlled release mechanism. CDA-NPs exhibited good pH sensitivity and controlled release properties in buffer solutions of different pH's at 1.2 and 6.8. The cumulative release of Rb
from CDA-NPs in simulated gastric fluid was <20 % within 2 h, while could release completely around 24 h in the simulated gastrointestinal fluid release system. It was demonstrated that CDA
-NPs can effectively control release and intelligently deliver ginsenoside Rb
, which is a promising alternative way for oral delivery.</description><subject>Alginates - chemistry</subject><subject>Chitosan - chemistry</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Deoxycholic Acid</subject><subject>Drug Carriers - chemistry</subject><subject>Ginsenosides</subject><subject>Hydrogen-Ion Concentration</subject><subject>Nanoparticles - chemistry</subject><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFj8FKQzEQRYMgtlp_QeYHAnk8bF_XpdKliPsyTaZ9U5LMI5Oq_RD_1yx07eqexeHAvTHzblitrXOun5l71XOj5XM33JlZvxxc17v13Hy_FpqwYGXJIEeYdlYpK1f-IPAjV1HMNpB8Xf0okT2g52BVAl8SYDxxxkqQMUvLVPaRFKJgoACfXEdoQguKciB4O0AHmANwVfCSa5EYm1goEipBIj9iZk0Lc3vEqPT4uw_m6WX7vtnZ6XJIFPZT4YTluv_70f8r_AAMzVbx</recordid><startdate>20230415</startdate><enddate>20230415</enddate><creator>Dong, Yujia</creator><creator>He, Yanhui</creator><creator>Fan, Daidi</creator><creator>Wu, Zhansheng</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20230415</creationdate><title>Preparation of pH-sensitive chitosan-deoxycholic acid-sodium alginate nanoparticles loaded with ginsenoside Rb 1 and its controlled release mechanism</title><author>Dong, Yujia ; He, Yanhui ; Fan, Daidi ; Wu, Zhansheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_368013093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alginates - chemistry</topic><topic>Chitosan - chemistry</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Deoxycholic Acid</topic><topic>Drug Carriers - chemistry</topic><topic>Ginsenosides</topic><topic>Hydrogen-Ion Concentration</topic><topic>Nanoparticles - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Yujia</creatorcontrib><creatorcontrib>He, Yanhui</creatorcontrib><creatorcontrib>Fan, Daidi</creatorcontrib><creatorcontrib>Wu, Zhansheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Yujia</au><au>He, Yanhui</au><au>Fan, Daidi</au><au>Wu, Zhansheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of pH-sensitive chitosan-deoxycholic acid-sodium alginate nanoparticles loaded with ginsenoside Rb 1 and its controlled release mechanism</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2023-04-15</date><risdate>2023</risdate><volume>234</volume><spage>123736</spage><pages>123736-</pages><eissn>1879-0003</eissn><abstract>Ginsenoside is a natural extract of the genus ginseng, which has tumor preventive and inhibiting effects. In this study, ginsenoside loaded nanoparticles were prepared by an ionic cross-linking method with sodium alginate to enable a sustained slow release effect of ginsenoside Rb
in the intestinal fluid through an intelligent response. Chitosan grafted hydrophobic group deoxycholic acid was used to synthesize CS-DA, providing loading space for hydrophobic Rb
. Scanning electron microscopy (SEM) showed that the nanoparticles was spherical with smooth surfaces. The encapsulation rate of Rb
enhanced with the increase of sodium alginate concentration and could reach to 76.62 ± 1.78 % when concentration was 3.6 mg/mL. It was found that the release process of CDA-NPs was most consistent with the primary kinetic model which is a diffusion-controlled release mechanism. CDA-NPs exhibited good pH sensitivity and controlled release properties in buffer solutions of different pH's at 1.2 and 6.8. The cumulative release of Rb
from CDA-NPs in simulated gastric fluid was <20 % within 2 h, while could release completely around 24 h in the simulated gastrointestinal fluid release system. It was demonstrated that CDA
-NPs can effectively control release and intelligently deliver ginsenoside Rb
, which is a promising alternative way for oral delivery.</abstract><cop>Netherlands</cop><pmid>36801309</pmid></addata></record> |
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| ispartof | International journal of biological macromolecules, 2023-04, Vol.234, p.123736 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alginates - chemistry Chitosan - chemistry Delayed-Action Preparations - chemistry Deoxycholic Acid Drug Carriers - chemistry Ginsenosides Hydrogen-Ion Concentration Nanoparticles - chemistry |
| title | Preparation of pH-sensitive chitosan-deoxycholic acid-sodium alginate nanoparticles loaded with ginsenoside Rb 1 and its controlled release mechanism |
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