Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene

Dietary 2-acetylaminofluorene (2-AAF) coupled with a stimulus for cell proliferation such as a 2/3 partial hepatectomy (PH) or a necrotizing dose of carbon tetrachloride is frequently employed to generate nodules of resistant ("initiated") rat hepatocytes. This regimen is a useful model fo...

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Veröffentlicht in:	International journal of cancer 1987-11, Vol.40 (5), p.643-645
Hauptverfasser:	SEMPLE-ROBERTS, E, HAYES, M. A, ARMSTRONG, D, BECKER, R. A, RACZ, W. J, FARBER, E
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Acetylaminofluorene Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens - administration & dosage Chemical agents Drug Resistance Liver - drug effects Liver - pathology Liver Neoplasms, Experimental - chemically induced Male Medical sciences Rats Rats, Inbred F344 Toxicology - methods Tumors
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