Hyperpolarized 13 C-Pyruvate to Assess Response to Anti-PD1 Immune Checkpoint Inhibition in YUMMER 1.7 Melanoma Xenografts

There is currently no consensus to determine which advanced melanoma patients will benefit from immunotherapy, highlighting the critical need to identify early-response biomarkers to immune checkpoint inhibitors. The aim of this work was to evaluate in vivo metabolic spectroscopy using hyperpolarize...

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Veröffentlicht in:	International journal of molecular sciences 2023-01, Vol.24 (3)
Hauptverfasser:	Farah, Chantale, Neveu, Marie-Aline, Bouzin, Caroline, Knezevic, Zorica, Gallez, Bernard, Leucci, Eleonora, Baurain, Jean-François, Mignion, Lionel, Jordan, Bénédicte F
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon Isotopes Glucose Heterografts Humans Immune Checkpoint Inhibitors Lactic Acid - metabolism Melanoma - drug therapy Pyruvic Acid - metabolism
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