Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery
This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2023-03, Vol.11 (1), p.2135-2144 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Shin, Kyounghee Lee, Kun Bong Hwang, Jee-Hyun Lee, Boryeong Ryu, Hyunsun Noh, Minjoo Lee, Jun Bae Nam, Yoon Sung Lim, Kyung-Min Kim, Jin Woong |
| description | This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone
N
-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function.
A multilamellar ceramide microvehicle platform was established by using cellulose nanofibers-enveloped ceramide-rich lipid microparticles (CerMPs). Our CerMPs with molecular layer integrity showed notable skin barrier function recovery performance. |
| doi_str_mv | 10.1039/d2tb02734h |
| format | Article |
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N
-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function.
A multilamellar ceramide microvehicle platform was established by using cellulose nanofibers-enveloped ceramide-rich lipid microparticles (CerMPs). Our CerMPs with molecular layer integrity showed notable skin barrier function recovery performance.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d2tb02734h</identifier><identifier>PMID: 36762491</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Alcohols ; Cellulose ; Cellulose fibers ; Ceramide ; Ceramides - chemistry ; Crystals ; Emulsions ; Epidermis ; Interlayers ; Lipids ; Microparticles ; Nanofibers ; Recovery ; Recovery of Function ; Skin ; Stearic acid ; Stoichiometry ; Structural integrity ; Water - chemistry ; Water loss</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2023-03, Vol.11 (1), p.2135-2144</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-b252466536abd69f17b8fd17f16546afdecf7887e7216df7f0d0123b6e82cae23</citedby><cites>FETCH-LOGICAL-c337t-b252466536abd69f17b8fd17f16546afdecf7887e7216df7f0d0123b6e82cae23</cites><orcidid>0000-0002-7302-6928 ; 0000-0002-6485-9936</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36762491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Kyounghee</creatorcontrib><creatorcontrib>Lee, Kun Bong</creatorcontrib><creatorcontrib>Hwang, Jee-Hyun</creatorcontrib><creatorcontrib>Lee, Boryeong</creatorcontrib><creatorcontrib>Ryu, Hyunsun</creatorcontrib><creatorcontrib>Noh, Minjoo</creatorcontrib><creatorcontrib>Lee, Jun Bae</creatorcontrib><creatorcontrib>Nam, Yoon Sung</creatorcontrib><creatorcontrib>Lim, Kyung-Min</creatorcontrib><creatorcontrib>Kim, Jin Woong</creatorcontrib><title>Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone
N
-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function.
A multilamellar ceramide microvehicle platform was established by using cellulose nanofibers-enveloped ceramide-rich lipid microparticles (CerMPs). Our CerMPs with molecular layer integrity showed notable skin barrier function recovery performance.</description><subject>Alcohols</subject><subject>Cellulose</subject><subject>Cellulose fibers</subject><subject>Ceramide</subject><subject>Ceramides - chemistry</subject><subject>Crystals</subject><subject>Emulsions</subject><subject>Epidermis</subject><subject>Interlayers</subject><subject>Lipids</subject><subject>Microparticles</subject><subject>Nanofibers</subject><subject>Recovery</subject><subject>Recovery of Function</subject><subject>Skin</subject><subject>Stearic acid</subject><subject>Stoichiometry</subject><subject>Structural integrity</subject><subject>Water - chemistry</subject><subject>Water loss</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0ctrFTEUB-Agii21G_dKwE0pjOYxk-Qube1DqHTTgrshk5xwU-dRT5KW_vfmetsrmE0C-XI45xdC3nP2mTO5-uJFHpjQsl2_IvuCdazRHTevd2f2c48cpnTH6jJcGdm-JXtSaSXaFd8n_kcZcxztBONokTpAO0UP1C0ITcpYXC4Ink7R4fIA6-hGSPQx5jVNZUjZzjnakaZfcaaDRYyANJTZ5bjMFMHVN_j0jrwJdkxw-LwfkNvzs5vTy-bq-uL76derxkmpczOITrRKdVLZwatV4HowwXMduOpaZYMHF7QxGrTgygcdmGdcyEGBEc6CkAfkaFv3HpffBVLup5jcZrIZlpJ6oXWnuOGsq_TTf_RuKTjX7qoy7SZQJqs63qo6fEoIob_HOFl86jnrN_H338TNyd_4Lyv--FyyDBP4HX0Ju4IPW4DJ7W7__Z_8A6g-i0k</recordid><startdate>20230308</startdate><enddate>20230308</enddate><creator>Shin, Kyounghee</creator><creator>Lee, Kun Bong</creator><creator>Hwang, Jee-Hyun</creator><creator>Lee, Boryeong</creator><creator>Ryu, Hyunsun</creator><creator>Noh, Minjoo</creator><creator>Lee, Jun Bae</creator><creator>Nam, Yoon Sung</creator><creator>Lim, Kyung-Min</creator><creator>Kim, Jin Woong</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7302-6928</orcidid><orcidid>https://orcid.org/0000-0002-6485-9936</orcidid></search><sort><creationdate>20230308</creationdate><title>Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery</title><author>Shin, Kyounghee ; Lee, Kun Bong ; Hwang, Jee-Hyun ; Lee, Boryeong ; Ryu, Hyunsun ; Noh, Minjoo ; Lee, Jun Bae ; Nam, Yoon Sung ; Lim, Kyung-Min ; Kim, Jin Woong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-b252466536abd69f17b8fd17f16546afdecf7887e7216df7f0d0123b6e82cae23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alcohols</topic><topic>Cellulose</topic><topic>Cellulose fibers</topic><topic>Ceramide</topic><topic>Ceramides - chemistry</topic><topic>Crystals</topic><topic>Emulsions</topic><topic>Epidermis</topic><topic>Interlayers</topic><topic>Lipids</topic><topic>Microparticles</topic><topic>Nanofibers</topic><topic>Recovery</topic><topic>Recovery of Function</topic><topic>Skin</topic><topic>Stearic acid</topic><topic>Stoichiometry</topic><topic>Structural integrity</topic><topic>Water - chemistry</topic><topic>Water loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Kyounghee</creatorcontrib><creatorcontrib>Lee, Kun Bong</creatorcontrib><creatorcontrib>Hwang, Jee-Hyun</creatorcontrib><creatorcontrib>Lee, Boryeong</creatorcontrib><creatorcontrib>Ryu, Hyunsun</creatorcontrib><creatorcontrib>Noh, Minjoo</creatorcontrib><creatorcontrib>Lee, Jun Bae</creatorcontrib><creatorcontrib>Nam, Yoon Sung</creatorcontrib><creatorcontrib>Lim, Kyung-Min</creatorcontrib><creatorcontrib>Kim, Jin Woong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Kyounghee</au><au>Lee, Kun Bong</au><au>Hwang, Jee-Hyun</au><au>Lee, Boryeong</au><au>Ryu, Hyunsun</au><au>Noh, Minjoo</au><au>Lee, Jun Bae</au><au>Nam, Yoon Sung</au><au>Lim, Kyung-Min</au><au>Kim, Jin Woong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2023-03-08</date><risdate>2023</risdate><volume>11</volume><issue>1</issue><spage>2135</spage><epage>2144</epage><pages>2135-2144</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone
N
-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function.
A multilamellar ceramide microvehicle platform was established by using cellulose nanofibers-enveloped ceramide-rich lipid microparticles (CerMPs). Our CerMPs with molecular layer integrity showed notable skin barrier function recovery performance.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36762491</pmid><doi>10.1039/d2tb02734h</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7302-6928</orcidid><orcidid>https://orcid.org/0000-0002-6485-9936</orcidid></addata></record> |
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| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2023-03, Vol.11 (1), p.2135-2144 |
| issn | 2050-750X 2050-7518 |
| language | eng |
| recordid | cdi_pubmed_primary_36762491 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Alcohols Cellulose Cellulose fibers Ceramide Ceramides - chemistry Crystals Emulsions Epidermis Interlayers Lipids Microparticles Nanofibers Recovery Recovery of Function Skin Stearic acid Stoichiometry Structural integrity Water - chemistry Water loss |
| title | Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery |
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