Visible-light-induced reactions of methylenecyclopropanes (MCPs)

Diverse, visible-light-induced transformations of methylenecyclopropanes (MCPs) have been reported in recent years, attracting significant attention from synthetic chemists. As readily accessible strained molecules, MCPs have sufficient reactivity to selectively generate different target products, through reactions with various radical species upon visible-light irradiation under regulated reaction conditions. These transformations can be classified into three subcategories of reaction pathway, forming ring-opened products, cyclopropane derivatives, and alkynes. These products include pharmaceutical intermediates and polycyclic/heterocyclic compounds that are challenging to obtain using traditional methods. This review summarizes the recent advancements in this field. We describe recent achievements in the visible-light-induced chemical transformations of methylenecyclopropanes (MCPs), including ring-opening reactions, cyclopropane-producing reactions, and ring-opening reactions via a non-classical radical clock.