Sigma-1 receptor modulation fine-tunes K V 1.5 channels and impacts pulmonary vascular function

K 1.5 channels are key players in the regulation of vascular tone and atrial excitability and their impairment is associated with cardiovascular diseases including pulmonary arterial hypertension (PAH) and atrial fibrillation (AF). Unfortunately, pharmacological strategies to improve K 1.5 channel f...

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Veröffentlicht in:	Pharmacological research 2023-03, Vol.189, p.106684
Hauptverfasser:	Vera-Zambrano, Alba, Baena-Nuevo, Maria, Rinné, Susanne, Villegas-Esguevillas, Marta, Barreira, Bianca, Telli, Gokcen, de Benito-Bueno, Angela, Blázquez, José Antonio, Climent, Belén, Pérez-Vizcaino, Francisco, Valenzuela, Carmen, Decher, Niels, Gonzalez, Teresa, Cogolludo, Angel
Format:	Artikel
Sprache:	eng
Schlagworte:	Atrial Fibrillation HEK293 Cells Humans Lung - pathology Pulmonary Artery Receptors, sigma - metabolism Sigma-1 Receptor
Online-Zugang:	Volltext
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