Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway
Panax ginseng C. A. Meyer (Araliaceae) is a tonic herb used in ancient Asia. This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats. Sprague-Dawley rats were divided into control, model and EEP (ethanol extraction of P. ginseng roots) (50, 100 and 200 mg/kg) groups (n =...
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| creator | Zhang, Guolei Lu, BoFan Wang, Enhui Wang, Wei Li, Zheng Jiao, Lili Li, Hui Wu, Wei |
| description | Panax ginseng C. A. Meyer (Araliaceae) is a tonic herb used in ancient Asia.
This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats.
Sprague-Dawley rats were divided into control, model and EEP (ethanol extraction of P. ginseng roots) (50, 100 and 200 mg/kg) groups (n = 8). The rats were subcutaneously handled with loaded swimming once daily for 26 days, except for the control group. The animals were intragastrically treated with EEP from the 15th day. On day 30, serum, liver and muscles were collected, and the PI3K/Akt/mTOR signalling pathway was evaluated.
The swimming times to exhaust of the rats with EEP were significantly longer than that without it. EEP spared the amount of muscle glycogen, hepatic glycogen and blood sugar under the chronic state. In addition, EEP significantly (p |
| doi_str_mv | 10.1080/13880209.2023.2169719 |
| format | Article |
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This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats.
Sprague-Dawley rats were divided into control, model and EEP (ethanol extraction of P. ginseng roots) (50, 100 and 200 mg/kg) groups (n = 8). The rats were subcutaneously handled with loaded swimming once daily for 26 days, except for the control group. The animals were intragastrically treated with EEP from the 15th day. On day 30, serum, liver and muscles were collected, and the PI3K/Akt/mTOR signalling pathway was evaluated.
The swimming times to exhaust of the rats with EEP were significantly longer than that without it. EEP spared the amount of muscle glycogen, hepatic glycogen and blood sugar under the chronic state. In addition, EEP significantly (p < 0.05) decreased serum triglycerides (1.24 ± 0.17, 1.29 ± 0.04 and 1.20 ± 0.21 vs. 1.58 ± 0.13 mmol/L) and total cholesterol (1.64 ± 0.36, 1.70 ± 0.15 and 1.41 ± 0.19 vs. 2.22 ± 0.19 mmol/L) compared to the model group. Regarding the regulation of energy, EEP had a positive impact on promoting ATPase activities and relative protein expression of the PI3K/Akt/mTOR pathway.
Our results suggested that EEP effectively relieved chronic fatigue, providing evidence that P. ginseng could be a potential dietary supplement to accelerate recovery from fatigue.</description><identifier>ISSN: 1388-0209</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1080/13880209.2023.2169719</identifier><identifier>PMID: 36695132</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Animals ; antifatigue ; Bioengineering ; Biology ; Cholesterol ; Chromatography ; Dietary supplements ; Energy ; Energy utilization ; Ethanol ; Exercise ; Fatigue Syndrome, Chronic ; Ginseng ; Glycogen ; Herb ; Kinases ; Laboratory animals ; Mass spectrometry ; Medicine ; Metabolism ; Metabolites ; Muscles ; Panax ; Panax ginseng ; Phosphatidylinositol 3-Kinases ; Physical fitness ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Proteins ; Proto-Oncogene Proteins c-akt ; Rats ; Rats, Sprague-Dawley ; saponin ; Scientific imaging ; Signal transduction ; Swimming ; TOR protein ; TOR Serine-Threonine Kinases ; Triglycerides ; UPLC-MS</subject><ispartof>Pharmaceutical biology, 2023-12, Vol.61 (1), p.316-323</ispartof><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2023</rights><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2023 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-f6ad0d7f10346094fed0a5db12bdb886761a5f781f713732c5a9ccef43e4e6323</citedby><cites>FETCH-LOGICAL-c562t-f6ad0d7f10346094fed0a5db12bdb886761a5f781f713732c5a9ccef43e4e6323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879180/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879180/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,27507,27929,27930,53796,53798,59148,59149</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36695132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Guolei</creatorcontrib><creatorcontrib>Lu, BoFan</creatorcontrib><creatorcontrib>Wang, Enhui</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Li, Zheng</creatorcontrib><creatorcontrib>Jiao, Lili</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Wu, Wei</creatorcontrib><title>Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway</title><title>Pharmaceutical biology</title><addtitle>Pharm Biol</addtitle><description>Panax ginseng C. A. Meyer (Araliaceae) is a tonic herb used in ancient Asia.
This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats.
Sprague-Dawley rats were divided into control, model and EEP (ethanol extraction of P. ginseng roots) (50, 100 and 200 mg/kg) groups (n = 8). The rats were subcutaneously handled with loaded swimming once daily for 26 days, except for the control group. The animals were intragastrically treated with EEP from the 15th day. On day 30, serum, liver and muscles were collected, and the PI3K/Akt/mTOR signalling pathway was evaluated.
The swimming times to exhaust of the rats with EEP were significantly longer than that without it. EEP spared the amount of muscle glycogen, hepatic glycogen and blood sugar under the chronic state. In addition, EEP significantly (p < 0.05) decreased serum triglycerides (1.24 ± 0.17, 1.29 ± 0.04 and 1.20 ± 0.21 vs. 1.58 ± 0.13 mmol/L) and total cholesterol (1.64 ± 0.36, 1.70 ± 0.15 and 1.41 ± 0.19 vs. 2.22 ± 0.19 mmol/L) compared to the model group. Regarding the regulation of energy, EEP had a positive impact on promoting ATPase activities and relative protein expression of the PI3K/Akt/mTOR pathway.
Our results suggested that EEP effectively relieved chronic fatigue, providing evidence that P. ginseng could be a potential dietary supplement to accelerate recovery from fatigue.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Animals</subject><subject>antifatigue</subject><subject>Bioengineering</subject><subject>Biology</subject><subject>Cholesterol</subject><subject>Chromatography</subject><subject>Dietary supplements</subject><subject>Energy</subject><subject>Energy utilization</subject><subject>Ethanol</subject><subject>Exercise</subject><subject>Fatigue Syndrome, Chronic</subject><subject>Ginseng</subject><subject>Glycogen</subject><subject>Herb</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Mass spectrometry</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Muscles</subject><subject>Panax</subject><subject>Panax ginseng</subject><subject>Phosphatidylinositol 3-Kinases</subject><subject>Physical fitness</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-akt</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>saponin</subject><subject>Scientific imaging</subject><subject>Signal transduction</subject><subject>Swimming</subject><subject>TOR protein</subject><subject>TOR Serine-Threonine Kinases</subject><subject>Triglycerides</subject><subject>UPLC-MS</subject><issn>1388-0209</issn><issn>1744-5116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9kstuEzEUhkcIREvhEUCW2LBJ4svYM94gqopL1EqtUFhbZzz2xNHEDvZMy_ACvDYOSSvKAsnSsX5__o8vf1G8JnhOcI0XhNU1pljOKaZsTomQFZFPilNSleWMEyKe5nlmZnvopHiR0gZjzBnjz4sTJoTkhNHT4tcNePiBOueT8R1y210Mtyah3XpKTkOPotFZiBMC3yLjTewmNA6udz9hcMGjPPQ6Bu80slnpRoOcRxGGhIasj906V4NuluxycX65WmxX119Rcp2Hvne54w6G9R1ML4tnFvpkXh3rWfHt08fVxZfZ1fXn5cX51UxzQYeZFdDitrIEs1JgWVrTYuBtQ2jTNnUtKkGA26omtiKsYlRzkFobWzJTGsEoOyuWB982wEbtottCnFQAp_4IIXYK4uB0b5SuW8YbACK5LWkjJNNGSs1oSQxuuMle7w9eu7HZmlYbP0ToH5k-XvFurbpwq2RdSVLjbPDuaBDD99GkQW1d0qbvwZswJkWr_E2SMskz-vYfdBPGmB8xU5JUvBSy3FP8QOkYUorGPhyGYLWPjbqPjdrHRh1jk_e9-fsmD7vuc5KBDwfAeRviFu5C7Fs1wNSHaCN47ZJi_-_xG8a60_E</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Zhang, Guolei</creator><creator>Lu, BoFan</creator><creator>Wang, Enhui</creator><creator>Wang, Wei</creator><creator>Li, Zheng</creator><creator>Jiao, Lili</creator><creator>Li, Hui</creator><creator>Wu, Wei</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>202312</creationdate><title>Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway</title><author>Zhang, Guolei ; Lu, BoFan ; Wang, Enhui ; Wang, Wei ; Li, Zheng ; Jiao, Lili ; Li, Hui ; Wu, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-f6ad0d7f10346094fed0a5db12bdb886761a5f781f713732c5a9ccef43e4e6323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Animals</topic><topic>antifatigue</topic><topic>Bioengineering</topic><topic>Biology</topic><topic>Cholesterol</topic><topic>Chromatography</topic><topic>Dietary supplements</topic><topic>Energy</topic><topic>Energy utilization</topic><topic>Ethanol</topic><topic>Exercise</topic><topic>Fatigue Syndrome, Chronic</topic><topic>Ginseng</topic><topic>Glycogen</topic><topic>Herb</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Mass spectrometry</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Muscles</topic><topic>Panax</topic><topic>Panax ginseng</topic><topic>Phosphatidylinositol 3-Kinases</topic><topic>Physical fitness</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins c-akt</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>saponin</topic><topic>Scientific imaging</topic><topic>Signal transduction</topic><topic>Swimming</topic><topic>TOR protein</topic><topic>TOR Serine-Threonine Kinases</topic><topic>Triglycerides</topic><topic>UPLC-MS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Guolei</creatorcontrib><creatorcontrib>Lu, BoFan</creatorcontrib><creatorcontrib>Wang, Enhui</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Li, Zheng</creatorcontrib><creatorcontrib>Jiao, Lili</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Wu, Wei</creatorcontrib><collection>Access via Taylor & Francis (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Pharmaceutical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Guolei</au><au>Lu, BoFan</au><au>Wang, Enhui</au><au>Wang, Wei</au><au>Li, Zheng</au><au>Jiao, Lili</au><au>Li, Hui</au><au>Wu, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway</atitle><jtitle>Pharmaceutical biology</jtitle><addtitle>Pharm Biol</addtitle><date>2023-12</date><risdate>2023</risdate><volume>61</volume><issue>1</issue><spage>316</spage><epage>323</epage><pages>316-323</pages><issn>1388-0209</issn><eissn>1744-5116</eissn><abstract>Panax ginseng C. A. Meyer (Araliaceae) is a tonic herb used in ancient Asia.
This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats.
Sprague-Dawley rats were divided into control, model and EEP (ethanol extraction of P. ginseng roots) (50, 100 and 200 mg/kg) groups (n = 8). The rats were subcutaneously handled with loaded swimming once daily for 26 days, except for the control group. The animals were intragastrically treated with EEP from the 15th day. On day 30, serum, liver and muscles were collected, and the PI3K/Akt/mTOR signalling pathway was evaluated.
The swimming times to exhaust of the rats with EEP were significantly longer than that without it. EEP spared the amount of muscle glycogen, hepatic glycogen and blood sugar under the chronic state. In addition, EEP significantly (p < 0.05) decreased serum triglycerides (1.24 ± 0.17, 1.29 ± 0.04 and 1.20 ± 0.21 vs. 1.58 ± 0.13 mmol/L) and total cholesterol (1.64 ± 0.36, 1.70 ± 0.15 and 1.41 ± 0.19 vs. 2.22 ± 0.19 mmol/L) compared to the model group. Regarding the regulation of energy, EEP had a positive impact on promoting ATPase activities and relative protein expression of the PI3K/Akt/mTOR pathway.
Our results suggested that EEP effectively relieved chronic fatigue, providing evidence that P. ginseng could be a potential dietary supplement to accelerate recovery from fatigue.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>36695132</pmid><doi>10.1080/13880209.2023.2169719</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Animals antifatigue Bioengineering Biology Cholesterol Chromatography Dietary supplements Energy Energy utilization Ethanol Exercise Fatigue Syndrome, Chronic Ginseng Glycogen Herb Kinases Laboratory animals Mass spectrometry Medicine Metabolism Metabolites Muscles Panax Panax ginseng Phosphatidylinositol 3-Kinases Physical fitness Plant Extracts - pharmacology Plant Extracts - therapeutic use Proteins Proto-Oncogene Proteins c-akt Rats Rats, Sprague-Dawley saponin Scientific imaging Signal transduction Swimming TOR protein TOR Serine-Threonine Kinases Triglycerides UPLC-MS |
| title | Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway |
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