TRPML1-Induced Lysosomal Ca 2+ Signals Activate AQP2 Translocation and Water Flux in Renal Collecting Duct Cells

Lysosomes are acidic Ca storage organelles that actively generate local Ca signaling events to regulate a plethora of cell functions. Here, we characterized lysosomal Ca signals in mouse renal collecting duct (CD) cells and we assessed their putative role in aquaporin 2 (AQP2)-dependent water reabso...

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Veröffentlicht in:	International journal of molecular sciences 2023-01, Vol.24 (2)
Hauptverfasser:	Scorza, Simona Ida, Milano, Serena, Saponara, Ilenia, Certini, Maira, De Zio, Roberta, Mola, Maria Grazia, Procino, Giuseppe, Carmosino, Monica, Moccia, Francesco, Svelto, Maria, Gerbino, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaporin 2 - genetics Aquaporin 2 - metabolism Kidney Tubules, Collecting - cytology Kidney Tubules, Collecting - metabolism Lysosomes - genetics Lysosomes - metabolism Macrolides - metabolism Macrolides - pharmacology Mice Water - metabolism
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