The Design, Synthesis, and Evaluation of Diaminopimelic Acid Derivatives as Potential dap F Inhibitors Preventing Lysine Biosynthesis for Antibacterial Activity

We created thiazole and oxazole analogues of diaminopimelic acid (DAP) by replacing its carboxyl groups and substituting sulphur for the central carbon atom. Toxicity, ADME, molecular docking, and in vitro antimicrobial studies of the synthesized compounds were carried out. These compounds displayed...

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Veröffentlicht in:	Antibiotics (Basel) 2022-12, Vol.12 (1)
Hauptverfasser:	Shaikh, Mohd Sayeed, Kale, Mayura A, Muralidharan, V, Venkatachalam, T, Ali, Syed Sarfaraz, Islam, Fahadul, Khan, Sharuk L, Siddiqui, Falak A, Urmee, Humaira, Tapadiya, Ganesh G, Dhawale, Sachin A, Ming, Long Chiau, Ibrahim, Ibrahim Abdel Aziz, Alzahrani, Abdullah R, Sarker, Md Moklesur Rahman, Azlina, Mohd Fahami Nur
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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