Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation

Cisplatin-induced ototoxicity is caused by reactive oxygen species. It has been recognized that estradiol (E2) regulates redox balance. However, little is known about the protective mechanisms of E2 against cisplatin-induced ototoxicity. In this study, we investigated the effect of E2 on nuclear fac...

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Veröffentlicht in:	Redox report : communications in free radical research 2023-12, Vol.28 (1), p.2161224
Hauptverfasser:	Adachi, Masahiro, Yanagizono, Kota, Okano, Yasuhito, Koizumi, Hitoshi, Uemaetomari, Isao, Tabuchi, Keiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - toxicity Apoptosis Cisplatin Cisplatin - toxicity cochlea hair cell estradiol Estradiol - metabolism Estradiol - pharmacology GSTA4 Hair Cells, Auditory - metabolism Mice Mice, Inbred C57BL NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 organ of corti ototoxicity Ototoxicity - metabolism reactive oxygen species Reactive Oxygen Species - metabolism RNA, Messenger - metabolism RNA, Messenger - pharmacology
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