Relationship between modulation of natural killer cell activity and antitumor activity of bropirimine when used in combination with various types of chemotherapeutic drugs

Bropirimine (ABPP), a pyrimidinone, is currently under clinical trial for its antitumor potential. Bropirimine alone was marginally active against some experimental tumors such as B16 melanoma but was ineffective against others such as P388 or L1210 leukemia. However, it produced statistically signi...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1987-11, Vol.47 (22), p.5894-5900
Hauptverfasser:	LI, L. H, DEKONING, T. F, WALLACE, T. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Applied sciences Biological and medical sciences Chemotherapy Cisplatin - administration & dosage Cisplatin - therapeutic use Cyclophosphamide - administration & dosage Cyclophosphamide - therapeutic use Cytosine - administration & dosage Cytosine - analogs & derivatives Cytosine - pharmacology Cytosine - therapeutic use Cytotoxicity, Immunologic - drug effects Dactinomycin - pharmacology Drug Synergism Exact sciences and technology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Leukemia P388 - drug therapy Leukemia, Experimental - drug therapy Male Medical sciences Mice Mice, Inbred Strains Other techniques and industries Pharmacology. Drug treatments
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