Inhibition of the proton-activated chloride channel PAC by PIP 2

Proton-activated chloride (PAC) channel is a ubiquitously expressed pH-sensing ion channel, encoded by ( ). PAC regulates endosomal acidification and macropinosome shrinkage by releasing chloride from the organelle lumens. It is also found at the cell surface, where it is activated under pathologica...

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Veröffentlicht in:	eLife 2023-01, Vol.12
Hauptverfasser:	Mihaljević, Ljubica, Ruan, Zheng, Osei-Owusu, James, Lü, Wei, Qiu, Zhaozhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Chloride Channels - metabolism Chlorides - metabolism Cryoelectron Microscopy Phosphatidylinositol 4,5-Diphosphate - metabolism Protein Domains Protons
Online-Zugang:	Volltext
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