CYP3A5 Expressor Genotype of the Transplanted Kidney Increases the Risk of Preterm Graft Loss and Acute Rejection

Introduction: Tacrolimus is metabolized mainly in the liver by the CYP3A enzyme family, with a particularly well-documented role of CYP3A5. CYP3A5 is also expressed in the renal tissue and is present in the transplanted kidney. To date, the association between donor CYP3A5 polymorphisms and transpla...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nephron (2015) 2023-07, Vol.147 (7), p.441-450
Hauptverfasser:	Warzyszyńska, Karola, Zawistowski, Michał, Karpeta, Edyta, Jałbrzykowska, Agnieszka, Kosieradzki, Maciej
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytochrome P-450 CYP3A - genetics Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A - pharmacology Experimental Nephrology and Genetics: Research Article Genotype Graft Rejection - genetics Humans Immunosuppressive Agents Infant, Newborn Kidney - metabolism Polymorphism, Single Nucleotide Retrospective Studies Tacrolimus - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!