Dynamic PET/CT scan of 68 Ga-FAPI-04 for the optimal acquisition time in suspected malignant hepatic cancer patients
Dynamic PET/CT scan of Ga-FAPI-04 in patients with suspected malignant hepatic lesions were retrospectively analyzed to find the optimal acquisition time with better lesion detection rate. Twenty-two patients with lesions confirmed by CT or MRI were performed with dynamic Ga-FAPI-04 PET/CT scan. Tra...
Gespeichert in:
| Veröffentlicht in: | Abdominal radiology (New York) 2023-03, Vol.48 (3), p.895 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 895 |
| container_title | Abdominal radiology (New York) |
| container_volume | 48 |
| creator | Xing, Haiqun Hu, Guilan Zhu, Wenjia Dong, Chengyan Shi, Ximin Li, Fang Huo, Li |
| description | Dynamic PET/CT scan of
Ga-FAPI-04 in patients with suspected malignant hepatic lesions were retrospectively analyzed to find the optimal acquisition time with better lesion detection rate.
Twenty-two patients with lesions confirmed by CT or MRI were performed with dynamic
Ga-FAPI-04 PET/CT scan. Tracer uptake of lesions and normal organs at different time points were analyzed. Standardized uptake value (SUV) and tumor-to-background (TBR) were calculated based on the quantification of images.
SUV of normal organs decreased rapidly from 10 to 30 min and decreased gradually from 30 to 60 min. Besides, the uterus showed a particularly high uptake in all patients (12.62 ± 4.58 at 10 min p.i., 12.04 ± 3.99 at 30 min p.i., 10.92 ± 2.38 at 60 min p.i.). SUV of lesions decreased gradually, while TBR increased from 10- to 60-min post-injection. Visual analysis verified a comparable lesion detectability of 30 min and 60 min with images of 10 min showing a decreased lesion detection number.
This study revealed that similar detection rates were achieved at both 30 and 60 min, suggesting a static scan at 30 min to be appropriate in the clinic. Besides, although with high lesion uptake, early
Ga-FAPI-04 PET imaging at 10 min after tracer injection could cause missed lesion detection. |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_36583752</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>36583752</sourcerecordid><originalsourceid>FETCH-pubmed_primary_365837523</originalsourceid><addsrcrecordid>eNqFjrEOgjAYhBsTo0R9BfO_ALGAraxGQd0c2EmtP1IDpdIy8PbWRGeny12-3N2EBHHCeUgpS-dkZe2TUhpxFkUxm5F5wlma7FgcEHcctWiVhGtWbA4FWCk0dBXwFE4izPfXS0i3UHU9uBqhM061ogEhX4OyyqlOg08QlAY7WIPS4R08oR5aaAc1GuF8uS-V2MPHoHZ2SaaVaCyuvrog6zwrDufQDLcW76Xp_Uo_lr-byV_gDfvdSBs</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Dynamic PET/CT scan of 68 Ga-FAPI-04 for the optimal acquisition time in suspected malignant hepatic cancer patients</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Xing, Haiqun ; Hu, Guilan ; Zhu, Wenjia ; Dong, Chengyan ; Shi, Ximin ; Li, Fang ; Huo, Li</creator><creatorcontrib>Xing, Haiqun ; Hu, Guilan ; Zhu, Wenjia ; Dong, Chengyan ; Shi, Ximin ; Li, Fang ; Huo, Li</creatorcontrib><description>Dynamic PET/CT scan of
Ga-FAPI-04 in patients with suspected malignant hepatic lesions were retrospectively analyzed to find the optimal acquisition time with better lesion detection rate.
Twenty-two patients with lesions confirmed by CT or MRI were performed with dynamic
Ga-FAPI-04 PET/CT scan. Tracer uptake of lesions and normal organs at different time points were analyzed. Standardized uptake value (SUV) and tumor-to-background (TBR) were calculated based on the quantification of images.
SUV of normal organs decreased rapidly from 10 to 30 min and decreased gradually from 30 to 60 min. Besides, the uterus showed a particularly high uptake in all patients (12.62 ± 4.58 at 10 min p.i., 12.04 ± 3.99 at 30 min p.i., 10.92 ± 2.38 at 60 min p.i.). SUV of lesions decreased gradually, while TBR increased from 10- to 60-min post-injection. Visual analysis verified a comparable lesion detectability of 30 min and 60 min with images of 10 min showing a decreased lesion detection number.
This study revealed that similar detection rates were achieved at both 30 and 60 min, suggesting a static scan at 30 min to be appropriate in the clinic. Besides, although with high lesion uptake, early
Ga-FAPI-04 PET imaging at 10 min after tracer injection could cause missed lesion detection.</description><identifier>EISSN: 2366-0058</identifier><identifier>PMID: 36583752</identifier><language>eng</language><publisher>United States</publisher><subject>Female ; Fluorodeoxyglucose F18 ; Gallium Radioisotopes ; Humans ; Liver Neoplasms ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Retrospective Studies</subject><ispartof>Abdominal radiology (New York), 2023-03, Vol.48 (3), p.895</ispartof><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36583752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xing, Haiqun</creatorcontrib><creatorcontrib>Hu, Guilan</creatorcontrib><creatorcontrib>Zhu, Wenjia</creatorcontrib><creatorcontrib>Dong, Chengyan</creatorcontrib><creatorcontrib>Shi, Ximin</creatorcontrib><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Huo, Li</creatorcontrib><title>Dynamic PET/CT scan of 68 Ga-FAPI-04 for the optimal acquisition time in suspected malignant hepatic cancer patients</title><title>Abdominal radiology (New York)</title><addtitle>Abdom Radiol (NY)</addtitle><description>Dynamic PET/CT scan of
Ga-FAPI-04 in patients with suspected malignant hepatic lesions were retrospectively analyzed to find the optimal acquisition time with better lesion detection rate.
Twenty-two patients with lesions confirmed by CT or MRI were performed with dynamic
Ga-FAPI-04 PET/CT scan. Tracer uptake of lesions and normal organs at different time points were analyzed. Standardized uptake value (SUV) and tumor-to-background (TBR) were calculated based on the quantification of images.
SUV of normal organs decreased rapidly from 10 to 30 min and decreased gradually from 30 to 60 min. Besides, the uterus showed a particularly high uptake in all patients (12.62 ± 4.58 at 10 min p.i., 12.04 ± 3.99 at 30 min p.i., 10.92 ± 2.38 at 60 min p.i.). SUV of lesions decreased gradually, while TBR increased from 10- to 60-min post-injection. Visual analysis verified a comparable lesion detectability of 30 min and 60 min with images of 10 min showing a decreased lesion detection number.
This study revealed that similar detection rates were achieved at both 30 and 60 min, suggesting a static scan at 30 min to be appropriate in the clinic. Besides, although with high lesion uptake, early
Ga-FAPI-04 PET imaging at 10 min after tracer injection could cause missed lesion detection.</description><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Gallium Radioisotopes</subject><subject>Humans</subject><subject>Liver Neoplasms</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Positron-Emission Tomography</subject><subject>Retrospective Studies</subject><issn>2366-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjrEOgjAYhBsTo0R9BfO_ALGAraxGQd0c2EmtP1IDpdIy8PbWRGeny12-3N2EBHHCeUgpS-dkZe2TUhpxFkUxm5F5wlma7FgcEHcctWiVhGtWbA4FWCk0dBXwFE4izPfXS0i3UHU9uBqhM061ogEhX4OyyqlOg08QlAY7WIPS4R08oR5aaAc1GuF8uS-V2MPHoHZ2SaaVaCyuvrog6zwrDufQDLcW76Xp_Uo_lr-byV_gDfvdSBs</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Xing, Haiqun</creator><creator>Hu, Guilan</creator><creator>Zhu, Wenjia</creator><creator>Dong, Chengyan</creator><creator>Shi, Ximin</creator><creator>Li, Fang</creator><creator>Huo, Li</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202303</creationdate><title>Dynamic PET/CT scan of 68 Ga-FAPI-04 for the optimal acquisition time in suspected malignant hepatic cancer patients</title><author>Xing, Haiqun ; Hu, Guilan ; Zhu, Wenjia ; Dong, Chengyan ; Shi, Ximin ; Li, Fang ; Huo, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_365837523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Gallium Radioisotopes</topic><topic>Humans</topic><topic>Liver Neoplasms</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Positron-Emission Tomography</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xing, Haiqun</creatorcontrib><creatorcontrib>Hu, Guilan</creatorcontrib><creatorcontrib>Zhu, Wenjia</creatorcontrib><creatorcontrib>Dong, Chengyan</creatorcontrib><creatorcontrib>Shi, Ximin</creatorcontrib><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Huo, Li</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Abdominal radiology (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xing, Haiqun</au><au>Hu, Guilan</au><au>Zhu, Wenjia</au><au>Dong, Chengyan</au><au>Shi, Ximin</au><au>Li, Fang</au><au>Huo, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic PET/CT scan of 68 Ga-FAPI-04 for the optimal acquisition time in suspected malignant hepatic cancer patients</atitle><jtitle>Abdominal radiology (New York)</jtitle><addtitle>Abdom Radiol (NY)</addtitle><date>2023-03</date><risdate>2023</risdate><volume>48</volume><issue>3</issue><spage>895</spage><pages>895-</pages><eissn>2366-0058</eissn><abstract>Dynamic PET/CT scan of
Ga-FAPI-04 in patients with suspected malignant hepatic lesions were retrospectively analyzed to find the optimal acquisition time with better lesion detection rate.
Twenty-two patients with lesions confirmed by CT or MRI were performed with dynamic
Ga-FAPI-04 PET/CT scan. Tracer uptake of lesions and normal organs at different time points were analyzed. Standardized uptake value (SUV) and tumor-to-background (TBR) were calculated based on the quantification of images.
SUV of normal organs decreased rapidly from 10 to 30 min and decreased gradually from 30 to 60 min. Besides, the uterus showed a particularly high uptake in all patients (12.62 ± 4.58 at 10 min p.i., 12.04 ± 3.99 at 30 min p.i., 10.92 ± 2.38 at 60 min p.i.). SUV of lesions decreased gradually, while TBR increased from 10- to 60-min post-injection. Visual analysis verified a comparable lesion detectability of 30 min and 60 min with images of 10 min showing a decreased lesion detection number.
This study revealed that similar detection rates were achieved at both 30 and 60 min, suggesting a static scan at 30 min to be appropriate in the clinic. Besides, although with high lesion uptake, early
Ga-FAPI-04 PET imaging at 10 min after tracer injection could cause missed lesion detection.</abstract><cop>United States</cop><pmid>36583752</pmid></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2366-0058 |
| ispartof | Abdominal radiology (New York), 2023-03, Vol.48 (3), p.895 |
| issn | 2366-0058 |
| language | eng |
| recordid | cdi_pubmed_primary_36583752 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Female Fluorodeoxyglucose F18 Gallium Radioisotopes Humans Liver Neoplasms Positron Emission Tomography Computed Tomography Positron-Emission Tomography Retrospective Studies |
| title | Dynamic PET/CT scan of 68 Ga-FAPI-04 for the optimal acquisition time in suspected malignant hepatic cancer patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T19%3A19%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dynamic%20PET/CT%20scan%20of%2068%20Ga-FAPI-04%20for%20the%20optimal%20acquisition%20time%20in%20suspected%20malignant%20hepatic%20cancer%20patients&rft.jtitle=Abdominal%20radiology%20(New%20York)&rft.au=Xing,%20Haiqun&rft.date=2023-03&rft.volume=48&rft.issue=3&rft.spage=895&rft.pages=895-&rft.eissn=2366-0058&rft_id=info:doi/&rft_dat=%3Cpubmed%3E36583752%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/36583752&rfr_iscdi=true |