A pH-responsive T 1 -T 2 dual-modal MRI contrast agent for cancer imaging
Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO @MnO , which shows decreased T and T contrast intensity in normal physiological conditions. In the acid envir...
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| Veröffentlicht in: | Nature communications 2022-12, Vol.13 (1), p.7948 |
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| container_title | Nature communications |
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| creator | Lu, Hongwei Chen, An Zhang, Xindan Wei, Zixiang Cao, Rong Zhu, Yi Lu, Jingxiong Wang, Zhongling Tian, Leilei |
| description | Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO
@MnO
, which shows decreased T
and T
contrast intensity in normal physiological conditions. In the acid environment of tumor or inflamed tissue, the manganese dioxide (MnO
) layer decomposes into magnetically active Mn
(T
-weighted), and the T
and T
signals are sequentially recovered. In addition, both constrast quenching-activation degrees of T
and T
images can be accurately regulated by the silicon dioxide (SiO
) intermediate layer between superparamagnetic iron oxide (SPIO) and MnO
. Through the "dual-contrast enhanced subtraction" imaging processing technique, the contrast sensitivity of this MRI contrast agent is enhanced to a 12.3-time difference between diseased and normal tissue. Consequently, SPIO@SiO
@MnO
is successfully applied to trace the tiny liver metastases of approximately 0.5 mm and monitor tissue inflammation. |
| doi_str_mv | 10.1038/s41467-022-35655-x |
| format | Article |
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@MnO
, which shows decreased T
and T
contrast intensity in normal physiological conditions. In the acid environment of tumor or inflamed tissue, the manganese dioxide (MnO
) layer decomposes into magnetically active Mn
(T
-weighted), and the T
and T
signals are sequentially recovered. In addition, both constrast quenching-activation degrees of T
and T
images can be accurately regulated by the silicon dioxide (SiO
) intermediate layer between superparamagnetic iron oxide (SPIO) and MnO
. Through the "dual-contrast enhanced subtraction" imaging processing technique, the contrast sensitivity of this MRI contrast agent is enhanced to a 12.3-time difference between diseased and normal tissue. Consequently, SPIO@SiO
@MnO
is successfully applied to trace the tiny liver metastases of approximately 0.5 mm and monitor tissue inflammation.</description><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/s41467-022-35655-x</identifier><identifier>PMID: 36572677</identifier><language>eng</language><publisher>England</publisher><subject>Contrast Media ; Humans ; Hydrogen-Ion Concentration ; Liver Neoplasms - secondary ; Magnetic Resonance Imaging - methods ; Manganese Compounds ; Oxides ; Silicon Dioxide</subject><ispartof>Nature communications, 2022-12, Vol.13 (1), p.7948</ispartof><rights>2022. The Author(s).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-0507-7042 ; 0000-0002-2886-7410 ; 0000-0001-7542-0593 ; 0000-0001-6695-4614 ; 0000-0002-5477-1287</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36572677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Hongwei</creatorcontrib><creatorcontrib>Chen, An</creatorcontrib><creatorcontrib>Zhang, Xindan</creatorcontrib><creatorcontrib>Wei, Zixiang</creatorcontrib><creatorcontrib>Cao, Rong</creatorcontrib><creatorcontrib>Zhu, Yi</creatorcontrib><creatorcontrib>Lu, Jingxiong</creatorcontrib><creatorcontrib>Wang, Zhongling</creatorcontrib><creatorcontrib>Tian, Leilei</creatorcontrib><title>A pH-responsive T 1 -T 2 dual-modal MRI contrast agent for cancer imaging</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><description>Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO
@MnO
, which shows decreased T
and T
contrast intensity in normal physiological conditions. In the acid environment of tumor or inflamed tissue, the manganese dioxide (MnO
) layer decomposes into magnetically active Mn
(T
-weighted), and the T
and T
signals are sequentially recovered. In addition, both constrast quenching-activation degrees of T
and T
images can be accurately regulated by the silicon dioxide (SiO
) intermediate layer between superparamagnetic iron oxide (SPIO) and MnO
. Through the "dual-contrast enhanced subtraction" imaging processing technique, the contrast sensitivity of this MRI contrast agent is enhanced to a 12.3-time difference between diseased and normal tissue. Consequently, SPIO@SiO
@MnO
is successfully applied to trace the tiny liver metastases of approximately 0.5 mm and monitor tissue inflammation.</description><subject>Contrast Media</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Liver Neoplasms - secondary</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Manganese Compounds</subject><subject>Oxides</subject><subject>Silicon Dioxide</subject><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjb0OgjAYABsTI0R5AQfzvUC1f1AcjdHg4GLYSYVCMFBIC0bfXgadveWWSw6hNSVbSni8c4KKSGLCGOZhFIb4NUM-I4JiKhn3UODcg0zwPY2FWCCPR6FkkZQ-uhygT7DVru-Mq58aUqCAU2BQjKrBbVeoBq63C-SdGaxyA6hKmwHKzkKuTK4t1K2qalOt0LxUjdPB10u0OZ_SY4L78d7qIuvtFNp39nvzv8EH6iY95g</recordid><startdate>20221226</startdate><enddate>20221226</enddate><creator>Lu, Hongwei</creator><creator>Chen, An</creator><creator>Zhang, Xindan</creator><creator>Wei, Zixiang</creator><creator>Cao, Rong</creator><creator>Zhu, Yi</creator><creator>Lu, Jingxiong</creator><creator>Wang, Zhongling</creator><creator>Tian, Leilei</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0003-0507-7042</orcidid><orcidid>https://orcid.org/0000-0002-2886-7410</orcidid><orcidid>https://orcid.org/0000-0001-7542-0593</orcidid><orcidid>https://orcid.org/0000-0001-6695-4614</orcidid><orcidid>https://orcid.org/0000-0002-5477-1287</orcidid></search><sort><creationdate>20221226</creationdate><title>A pH-responsive T 1 -T 2 dual-modal MRI contrast agent for cancer imaging</title><author>Lu, Hongwei ; Chen, An ; Zhang, Xindan ; Wei, Zixiang ; Cao, Rong ; Zhu, Yi ; Lu, Jingxiong ; Wang, Zhongling ; Tian, Leilei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_365726773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Contrast Media</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Liver Neoplasms - secondary</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Manganese Compounds</topic><topic>Oxides</topic><topic>Silicon Dioxide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Hongwei</creatorcontrib><creatorcontrib>Chen, An</creatorcontrib><creatorcontrib>Zhang, Xindan</creatorcontrib><creatorcontrib>Wei, Zixiang</creatorcontrib><creatorcontrib>Cao, Rong</creatorcontrib><creatorcontrib>Zhu, Yi</creatorcontrib><creatorcontrib>Lu, Jingxiong</creatorcontrib><creatorcontrib>Wang, Zhongling</creatorcontrib><creatorcontrib>Tian, Leilei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Hongwei</au><au>Chen, An</au><au>Zhang, Xindan</au><au>Wei, Zixiang</au><au>Cao, Rong</au><au>Zhu, Yi</au><au>Lu, Jingxiong</au><au>Wang, Zhongling</au><au>Tian, Leilei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pH-responsive T 1 -T 2 dual-modal MRI contrast agent for cancer imaging</atitle><jtitle>Nature communications</jtitle><addtitle>Nat Commun</addtitle><date>2022-12-26</date><risdate>2022</risdate><volume>13</volume><issue>1</issue><spage>7948</spage><pages>7948-</pages><eissn>2041-1723</eissn><abstract>Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO
@MnO
, which shows decreased T
and T
contrast intensity in normal physiological conditions. In the acid environment of tumor or inflamed tissue, the manganese dioxide (MnO
) layer decomposes into magnetically active Mn
(T
-weighted), and the T
and T
signals are sequentially recovered. In addition, both constrast quenching-activation degrees of T
and T
images can be accurately regulated by the silicon dioxide (SiO
) intermediate layer between superparamagnetic iron oxide (SPIO) and MnO
. Through the "dual-contrast enhanced subtraction" imaging processing technique, the contrast sensitivity of this MRI contrast agent is enhanced to a 12.3-time difference between diseased and normal tissue. Consequently, SPIO@SiO
@MnO
is successfully applied to trace the tiny liver metastases of approximately 0.5 mm and monitor tissue inflammation.</abstract><cop>England</cop><pmid>36572677</pmid><doi>10.1038/s41467-022-35655-x</doi><orcidid>https://orcid.org/0000-0003-0507-7042</orcidid><orcidid>https://orcid.org/0000-0002-2886-7410</orcidid><orcidid>https://orcid.org/0000-0001-7542-0593</orcidid><orcidid>https://orcid.org/0000-0001-6695-4614</orcidid><orcidid>https://orcid.org/0000-0002-5477-1287</orcidid></addata></record> |
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| ispartof | Nature communications, 2022-12, Vol.13 (1), p.7948 |
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| language | eng |
| recordid | cdi_pubmed_primary_36572677 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Springer Nature OA/Free Journals |
| subjects | Contrast Media Humans Hydrogen-Ion Concentration Liver Neoplasms - secondary Magnetic Resonance Imaging - methods Manganese Compounds Oxides Silicon Dioxide |
| title | A pH-responsive T 1 -T 2 dual-modal MRI contrast agent for cancer imaging |
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