Gabapentin Disrupts Binding of Perlecan to the α 2 δ 1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation

Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified "tethering elements" (TEs) spanning the pericellular space of osteocytes and transmitting mechanical information into biochemical signals. While...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2022-12, Vol.12 (12)
Hauptverfasser:	Reyes Fernandez, Perla C, Wright, Christian S, Masterson, Adrianna N, Yi, Xin, Tellman, Tristen V, Bonteanu, Andrei, Rust, Katie, Noonan, Megan L, White, Kenneth E, Lewis, Karl J, Sankar, Uma, Hum, Julia M, Bix, Gregory, Wu, Danielle, Robling, Alexander G, Sardar, Rajesh, Farach-Carson, Mary C, Thompson, William R
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Channels - genetics Calcium Channels - metabolism Extracellular Matrix Proteins - metabolism Gabapentin - pharmacology Heparan Sulfate Proteoglycans - metabolism Mechanotransduction, Cellular
Online-Zugang:	Volltext
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