Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress

Andrographolide (Andr) is a bioactive Andr diterpenoid extracted from herbaceous Andrographis paniculata (Burm. F.) Wall. ex Nees (Acanthaceae). Andr can relieve cardiac dysfunction in mice by inhibiting the mitogen-activated protein kinases (MAPK) pathway. This study investigates the efficacy and u...

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Veröffentlicht in:	Pharmaceutical biology 2023-12, Vol.61 (1), p.61-68
Hauptverfasser:	Tian, Qingxin, Liu, Jianlong, Chen, Qin, Zhang, Mingxiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Animals Aorta Apoptosis cardiac fibrosis Cardiomegaly - drug therapy Cardiomegaly - pathology Cardiomyocytes Diterpenes Diterpenes - pharmacology Diterpenes - therapeutic use Endoplasmic reticulum Endoplasmic Reticulum Stress Fibrosis heart failure Hypertrophy Kinases Male MAP kinase Mice Mice, Inbred C57BL Myocytes, Cardiac - pathology pressure overload Transverse aortic constriction Tunicamycin
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