Ectoine gel transdermal formulation as a novel therapeutic approach in melanoma using 3D printed microneedles

A 7%w/w ectoine formula, from natural source, is formulated to reduce melanomagenesis, enhance penetration by 3D printed microneedles (MNs), with specified length, diameter and tip to ensure painless effect. Ectoine gel formulations were prepared using Carbopol 940 and Pluronic (F127). The effect of...

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Veröffentlicht in:	Pharmaceutical development and technology 2022-11, Vol.27 (10), p.1110-1124
Hauptverfasser:	Bayoumi, Sammar A., Dawaba, Aya M., Mansour, Ahmed, Zalat, Zeinab AlKasaby, Ammar, Amal A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3D printed microneedles Administration, Cutaneous Animals Ectoine ex vivo freeze-thaw cycle Gels - chemistry Male melanoma Melanoma - drug therapy Poloxamer - chemistry Printing, Three-Dimensional Rats Skin - metabolism Skin Absorption
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