Maternal Physiological Variations Induced by Chronic Gestational Hypoxia: 1 H NMR-Based Metabolomics Study
Metabolomics have been widely used in pregnancy-related diseases. However, physiological variations induced by chronic hypoxia during pregnancy are not well characterized. We aimed to investigate physiological variations induced by chronic hypoxia during pregnancy. A Sprague-Dawley (SD) pregnant rat...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2022-11, Vol.27 (22) |
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| container_title | Molecules (Basel, Switzerland) |
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| creator | Xie, Jing-Xian Chen, Qiu-Fang Fan, Yan-Feng Qin, Yao Zhang, Xue-Qin Zhong, Hong-Xiu |
| description | Metabolomics have been widely used in pregnancy-related diseases. However, physiological variations induced by chronic hypoxia during pregnancy are not well characterized. We aimed to investigate physiological variations induced by chronic hypoxia during pregnancy. A Sprague-Dawley (SD) pregnant rat model of chronic hypoxia was established. Plasma and urine metabolite profiles at different stages of the pregnancy were detected by
H NMR (nuclear magnetic resonance). Multivariate statistical analysis was used to analyze changes in plasma and urine metabolic trajectories at different time-points. We identified hypoxia-induced changes in the levels of 30 metabolites in plasma and 29 metabolites in urine during different stages of pregnancy; the prominently affected metabolites included acetic acid, acetone, choline, citric acid, glutamine, isoleucine, lysine, and serine. Most significant hypoxia-induced changes in plasma and urine sample metabolites were observed on the 11th day of gestation. In summary, chronic hypoxia has a significant effect on pregnant rats, and may cause metabolic disorders involving glucose, lipids, amino acids, and tricarboxylic acid cycle. Metabolomics study of the effect of hypoxia during pregnancy may provide insights into the pathogenesis of obstetric disorders. |
| doi_str_mv | 10.3390/molecules27228013 |
| format | Article |
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H NMR (nuclear magnetic resonance). Multivariate statistical analysis was used to analyze changes in plasma and urine metabolic trajectories at different time-points. We identified hypoxia-induced changes in the levels of 30 metabolites in plasma and 29 metabolites in urine during different stages of pregnancy; the prominently affected metabolites included acetic acid, acetone, choline, citric acid, glutamine, isoleucine, lysine, and serine. Most significant hypoxia-induced changes in plasma and urine sample metabolites were observed on the 11th day of gestation. In summary, chronic hypoxia has a significant effect on pregnant rats, and may cause metabolic disorders involving glucose, lipids, amino acids, and tricarboxylic acid cycle. Metabolomics study of the effect of hypoxia during pregnancy may provide insights into the pathogenesis of obstetric disorders.</description><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules27228013</identifier><identifier>PMID: 36432114</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Animals ; Female ; Hypoxia ; Magnetic Resonance Spectroscopy ; Metabolomics ; Pregnancy ; Proton Magnetic Resonance Spectroscopy ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Molecules (Basel, Switzerland), 2022-11, Vol.27 (22)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36432114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Jing-Xian</creatorcontrib><creatorcontrib>Chen, Qiu-Fang</creatorcontrib><creatorcontrib>Fan, Yan-Feng</creatorcontrib><creatorcontrib>Qin, Yao</creatorcontrib><creatorcontrib>Zhang, Xue-Qin</creatorcontrib><creatorcontrib>Zhong, Hong-Xiu</creatorcontrib><title>Maternal Physiological Variations Induced by Chronic Gestational Hypoxia: 1 H NMR-Based Metabolomics Study</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>Metabolomics have been widely used in pregnancy-related diseases. However, physiological variations induced by chronic hypoxia during pregnancy are not well characterized. We aimed to investigate physiological variations induced by chronic hypoxia during pregnancy. A Sprague-Dawley (SD) pregnant rat model of chronic hypoxia was established. Plasma and urine metabolite profiles at different stages of the pregnancy were detected by
H NMR (nuclear magnetic resonance). Multivariate statistical analysis was used to analyze changes in plasma and urine metabolic trajectories at different time-points. We identified hypoxia-induced changes in the levels of 30 metabolites in plasma and 29 metabolites in urine during different stages of pregnancy; the prominently affected metabolites included acetic acid, acetone, choline, citric acid, glutamine, isoleucine, lysine, and serine. Most significant hypoxia-induced changes in plasma and urine sample metabolites were observed on the 11th day of gestation. In summary, chronic hypoxia has a significant effect on pregnant rats, and may cause metabolic disorders involving glucose, lipids, amino acids, and tricarboxylic acid cycle. Metabolomics study of the effect of hypoxia during pregnancy may provide insights into the pathogenesis of obstetric disorders.</description><subject>Animals</subject><subject>Female</subject><subject>Hypoxia</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Metabolomics</subject><subject>Pregnancy</subject><subject>Proton Magnetic Resonance Spectroscopy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjs1KAzEUhUNBbG19gG7kvsBo_vypS4t2XEwRK27LnUy0KZnJkJsB8_YOomtXh4_zcTiMLQW_VGrFr9rgrRm8JXkr5R0XasJmQkteKK5XU3ZGdORcCi2uT9lU3WglhdAzdqww2dihh5dDJhd8-HRmpHeMDpMLHcFz1wzGNlBnWB9i6JyBjaX0045mmfvw5fAeBJSwrV6LB6TRrmzCepxrnSHYpaHJC3bygZ7s-W_O2cXT49u6LPqhbm2z76NrMeb93zn1r_ANR9xMBw</recordid><startdate>20221118</startdate><enddate>20221118</enddate><creator>Xie, Jing-Xian</creator><creator>Chen, Qiu-Fang</creator><creator>Fan, Yan-Feng</creator><creator>Qin, Yao</creator><creator>Zhang, Xue-Qin</creator><creator>Zhong, Hong-Xiu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20221118</creationdate><title>Maternal Physiological Variations Induced by Chronic Gestational Hypoxia: 1 H NMR-Based Metabolomics Study</title><author>Xie, Jing-Xian ; Chen, Qiu-Fang ; Fan, Yan-Feng ; Qin, Yao ; Zhang, Xue-Qin ; Zhong, Hong-Xiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_364321143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Female</topic><topic>Hypoxia</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Metabolomics</topic><topic>Pregnancy</topic><topic>Proton Magnetic Resonance Spectroscopy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Jing-Xian</creatorcontrib><creatorcontrib>Chen, Qiu-Fang</creatorcontrib><creatorcontrib>Fan, Yan-Feng</creatorcontrib><creatorcontrib>Qin, Yao</creatorcontrib><creatorcontrib>Zhang, Xue-Qin</creatorcontrib><creatorcontrib>Zhong, Hong-Xiu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Jing-Xian</au><au>Chen, Qiu-Fang</au><au>Fan, Yan-Feng</au><au>Qin, Yao</au><au>Zhang, Xue-Qin</au><au>Zhong, Hong-Xiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Physiological Variations Induced by Chronic Gestational Hypoxia: 1 H NMR-Based Metabolomics Study</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2022-11-18</date><risdate>2022</risdate><volume>27</volume><issue>22</issue><eissn>1420-3049</eissn><abstract>Metabolomics have been widely used in pregnancy-related diseases. However, physiological variations induced by chronic hypoxia during pregnancy are not well characterized. We aimed to investigate physiological variations induced by chronic hypoxia during pregnancy. A Sprague-Dawley (SD) pregnant rat model of chronic hypoxia was established. Plasma and urine metabolite profiles at different stages of the pregnancy were detected by
H NMR (nuclear magnetic resonance). Multivariate statistical analysis was used to analyze changes in plasma and urine metabolic trajectories at different time-points. We identified hypoxia-induced changes in the levels of 30 metabolites in plasma and 29 metabolites in urine during different stages of pregnancy; the prominently affected metabolites included acetic acid, acetone, choline, citric acid, glutamine, isoleucine, lysine, and serine. Most significant hypoxia-induced changes in plasma and urine sample metabolites were observed on the 11th day of gestation. In summary, chronic hypoxia has a significant effect on pregnant rats, and may cause metabolic disorders involving glucose, lipids, amino acids, and tricarboxylic acid cycle. Metabolomics study of the effect of hypoxia during pregnancy may provide insights into the pathogenesis of obstetric disorders.</abstract><cop>Switzerland</cop><pmid>36432114</pmid><doi>10.3390/molecules27228013</doi></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Female Hypoxia Magnetic Resonance Spectroscopy Metabolomics Pregnancy Proton Magnetic Resonance Spectroscopy Rats Rats, Sprague-Dawley |
| title | Maternal Physiological Variations Induced by Chronic Gestational Hypoxia: 1 H NMR-Based Metabolomics Study |
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