Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues

Analogues of the canonical nucleosides have a longstanding presence and proven capability within medicinal chemistry and drug discovery research. The synthesis reported herein successfully replaces furanose oxygen with CF 2 and CHF in pyrimidine nucleosides, granting access to an alternative pharmac...

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Veröffentlicht in:	Organic & biomolecular chemistry 2022-12, Vol.2 (47), p.9469-9489
Hauptverfasser:	Benckendorff, Caecilie M. M, Slyusarchuk, Valentyna D, Huang, Ningwu, Lima, Marcelo A, Smith, Mark, Miller, Gavin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell viability Chemical synthesis Chemistry, Pharmaceutical Crystallography Fluorination NMR Nuclear magnetic resonance Nucleoside analogs Nucleosides Nucleosides - pharmacology Oligonucleotides Pyrimidine Nucleosides - pharmacology Scaffolds Stereoselectivity X-ray crystallography
Online-Zugang:	Volltext
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