Avirulent phenotype promotes Bordetella pertussis adaptation to the intramacrophage environment

Bordetella pertussis, the causative agent of whooping cough, is an extracellular, strictly human pathogen. However, it has been shown that B. pertussis cells can escape phagocytic killing and survive in macrophages upon internalization. Our time-resolved RNA-seq data suggest that B. pertussis effici...

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Veröffentlicht in:	Emerging microbes & infections 2023-12, Vol.12 (1), p.e2146536
Hauptverfasser:	Farman, Mariam R., Petráčková, Denisa, Kumar, Dilip, Držmíšek, Jakub, Saha, Argha, Čurnová, Ivana, Čapek, Jan, Hejnarová, Václava, Amman, Fabian, Hofacker, Ivo, Večerek, Branislav
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation adaptation to stress avirulent phase Bacterial Proteins - genetics Bacterial Proteins - metabolism Bordetella pertussis Bordetella pertussis - metabolism BvgAS cysteine toxicity Gene Expression Regulation, Bacterial Humans intramacrophage environment Macrophages - metabolism Metabolism Phenotype Whooping Cough
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