A link between agrin signalling and Ca v 3.2 at the neuromuscular junction in spinal muscular atrophy

SMN protein deficiency causes motoneuron disease spinal muscular atrophy (SMA). SMN-based therapies improve patient motor symptoms to variable degrees. An early hallmark of SMA is the perturbation of the neuromuscular junction (NMJ), a synapse between a motoneuron and muscle cell. NMJ formation depe...

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Veröffentlicht in:	Scientific reports 2022-11, Vol.12 (1), p.18960
Hauptverfasser:	Delers, Perrine, Sapaly, Delphine, Salman, Badih, De Waard, Stephan, De Waard, Michel, Lefebvre, Suzie
Format:	Artikel
Sprache:	eng
Schlagworte:	Agrin - genetics Agrin - metabolism Animals Flunarizine Integrins - metabolism Mice Muscular Atrophy, Spinal - metabolism Neuromuscular Junction - metabolism Receptor Protein-Tyrosine Kinases - metabolism Receptors, Cholinergic - genetics Receptors, Cholinergic - metabolism
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