Fucoxanthin ameliorated myocardial fibrosis in STZ-induced diabetic rats and cell hypertrophy in HG-induced H9c2 cells by alleviating oxidative stress and restoring mitophagy

Diabetic cardiomyopathy (DCM) is one of the leading causes of death in diabetic patients, and is accompanied by increased oxidative stress and mitochondrial dysfunction. Fucoxanthin (FX), as a marine carotenoid, possesses strong antioxidant activity. The main purpose of our study was to explore whet...

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Veröffentlicht in:	Food & function 2022-09, Vol.13 (18), p.9559-9575
Hauptverfasser:	Zheng, Dongxiao, Chen, Linlin, Li, Guoping, Jin, Lin, Wei, Qihui, Liu, Zilue, Yang, Guanyu, Li, Yuanyuan, Xie, Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Autophagy BNIP3 protein Cardiomyopathy Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Diabetic Cardiomyopathies - drug therapy Fibrosis Fucoxanthin Functional foods & nutraceuticals Hypertrophy Lipid metabolism Lipids Mitochondria Mitophagy NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative Stress Rats Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Signaling Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Xanthophylls - pharmacology
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