AUGMENTATION OF DRUG-INDUCED LYMPHOCYTE TRANSFORMATION BY INDOMETHACIN IN PATIENTS WITH DRUG-INDUCED ALLERGIC HEPATITIS
Although lymphocyte transformation and lymphokine production have been frequently used for the identification of the causative drug in patients with drug-induced allergic hepatitis, these immunological parameters are not always positive in all patients. This may be reflected in the population of sup...
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| Veröffentlicht in: | Nippon Shokakibyo Gakkai Zasshi 1987, Vol.84(3), pp.719-725 |
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| container_issue | 3 |
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| container_title | Nippon Shokakibyo Gakkai Zasshi |
| container_volume | 84 |
| creator | MIZOGUCHI, Yasuhiro MIYAJIMA, Keiji KITAMURA, Mizuho TSUTSUI, Hiroko TAKEDA, Hiroshi SHIN, Tokan SAKAGAMI, Yoshihide SEKI, Shunichi KOBAYASHI, Kenzo YAMAMOTO, Sukeo MORISAWA, Seiji |
| description | Although lymphocyte transformation and lymphokine production have been frequently used for the identification of the causative drug in patients with drug-induced allergic hepatitis, these immunological parameters are not always positive in all patients. This may be reflected in the population of suppressor cells. In order to augment these immunological reactions, we devised a method in which indomethacin was added to the lymphocyte culture simultaneously with antigen (drug and carrier). In patients who did not show any positive lymphocyte transformation or lymphokine (cholestatic factor) production by stimulation with the causative drug in the presence of the suitable carrier, the addition of indomethacin was found to enhance the immunological responses. That is, lymphocyte transformation by the causative drug was significantly induced. |
| doi_str_mv | 10.11405/nisshoshi1964.84.719 |
| format | Article |
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This may be reflected in the population of suppressor cells. In order to augment these immunological reactions, we devised a method in which indomethacin was added to the lymphocyte culture simultaneously with antigen (drug and carrier). In patients who did not show any positive lymphocyte transformation or lymphokine (cholestatic factor) production by stimulation with the causative drug in the presence of the suitable carrier, the addition of indomethacin was found to enhance the immunological responses. That is, lymphocyte transformation by the causative drug was significantly induced.</description><subject>Animals</subject><subject>Chemical and Drug Induced Liver Injury - diagnosis</subject><subject>Drug Hypersensitivity - diagnosis</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Indomethacin - pharmacology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphokines - biosynthesis</subject><subject>Male</subject><subject>Rats</subject><issn>0446-6586</issn><issn>1349-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkNtqwkAURYfSYsX6CcL8QGzmPvOYxmgCuUicUHwKk1uNqBVjKf37pqQIvpzNYS32wwZghuw5QtRmr6e263af3a5FitO5pHOB1AMYI0KVJbgij2BsU8otziR_BtOuawvbthVTkpARGBGmFLPxGHw72SryYu3oIIlhsoSLNFtZQbzIXG8Bw2209hN3qz2oUyfeLJM0Gsy3LeylJPK077hB3D9w3ZO-aQPfA-3f9zhh6KWrwIW-92fpYPMCnhpz6Orpf05AtvS061th0ntOaO2R4NhCErOmMpUSkhWYlkSoRkkkS0VlSTBmZVFwiqWpcFGyQtjcGC4kNqJuKt5gMgGzoff8VRzrKj9f2qO5_OT_A_Q8GPi-u5qP-sbN5dqWhzq_2zmXNCfD6ee-OeXOXPL6RH4B0Itxww</recordid><startdate>198703</startdate><enddate>198703</enddate><creator>MIZOGUCHI, Yasuhiro</creator><creator>MIYAJIMA, Keiji</creator><creator>KITAMURA, Mizuho</creator><creator>TSUTSUI, Hiroko</creator><creator>TAKEDA, Hiroshi</creator><creator>SHIN, Tokan</creator><creator>SAKAGAMI, Yoshihide</creator><creator>SEKI, Shunichi</creator><creator>KOBAYASHI, Kenzo</creator><creator>YAMAMOTO, Sukeo</creator><creator>MORISAWA, Seiji</creator><general>The Japanese Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198703</creationdate><title>AUGMENTATION OF DRUG-INDUCED LYMPHOCYTE TRANSFORMATION BY INDOMETHACIN IN PATIENTS WITH DRUG-INDUCED ALLERGIC HEPATITIS</title><author>MIZOGUCHI, Yasuhiro ; MIYAJIMA, Keiji ; KITAMURA, Mizuho ; TSUTSUI, Hiroko ; TAKEDA, Hiroshi ; SHIN, Tokan ; SAKAGAMI, Yoshihide ; SEKI, Shunichi ; KOBAYASHI, Kenzo ; YAMAMOTO, Sukeo ; MORISAWA, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j1762-1825fdad9785b24c379f9818c948c3225cbb6428ad2bc5b706aa6782a7efd6f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Chemical and Drug Induced Liver Injury - diagnosis</topic><topic>Drug Hypersensitivity - diagnosis</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Indomethacin - pharmacology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphokines - biosynthesis</topic><topic>Male</topic><topic>Rats</topic><toplevel>online_resources</toplevel><creatorcontrib>MIZOGUCHI, Yasuhiro</creatorcontrib><creatorcontrib>MIYAJIMA, Keiji</creatorcontrib><creatorcontrib>KITAMURA, Mizuho</creatorcontrib><creatorcontrib>TSUTSUI, Hiroko</creatorcontrib><creatorcontrib>TAKEDA, Hiroshi</creatorcontrib><creatorcontrib>SHIN, Tokan</creatorcontrib><creatorcontrib>SAKAGAMI, Yoshihide</creatorcontrib><creatorcontrib>SEKI, Shunichi</creatorcontrib><creatorcontrib>KOBAYASHI, Kenzo</creatorcontrib><creatorcontrib>YAMAMOTO, Sukeo</creatorcontrib><creatorcontrib>MORISAWA, Seiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIZOGUCHI, Yasuhiro</au><au>MIYAJIMA, Keiji</au><au>KITAMURA, Mizuho</au><au>TSUTSUI, Hiroko</au><au>TAKEDA, Hiroshi</au><au>SHIN, Tokan</au><au>SAKAGAMI, Yoshihide</au><au>SEKI, Shunichi</au><au>KOBAYASHI, Kenzo</au><au>YAMAMOTO, Sukeo</au><au>MORISAWA, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AUGMENTATION OF DRUG-INDUCED LYMPHOCYTE TRANSFORMATION BY INDOMETHACIN IN PATIENTS WITH DRUG-INDUCED ALLERGIC HEPATITIS</atitle><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><date>1987-03</date><risdate>1987</risdate><volume>84</volume><issue>3</issue><spage>719</spage><epage>725</epage><pages>719-725</pages><issn>0446-6586</issn><eissn>1349-7693</eissn><abstract>Although lymphocyte transformation and lymphokine production have been frequently used for the identification of the causative drug in patients with drug-induced allergic hepatitis, these immunological parameters are not always positive in all patients. This may be reflected in the population of suppressor cells. In order to augment these immunological reactions, we devised a method in which indomethacin was added to the lymphocyte culture simultaneously with antigen (drug and carrier). In patients who did not show any positive lymphocyte transformation or lymphokine (cholestatic factor) production by stimulation with the causative drug in the presence of the suitable carrier, the addition of indomethacin was found to enhance the immunological responses. That is, lymphocyte transformation by the causative drug was significantly induced.</abstract><cop>Japan</cop><pub>The Japanese Society of Gastroenterology</pub><pmid>3599502</pmid><doi>10.11405/nisshoshi1964.84.719</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0446-6586 |
| ispartof | Nippon Shokakibyo Gakkai Zasshi, 1987, Vol.84(3), pp.719-725 |
| issn | 0446-6586 1349-7693 |
| language | jpn |
| recordid | cdi_pubmed_primary_3599502 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Chemical and Drug Induced Liver Injury - diagnosis Drug Hypersensitivity - diagnosis Guinea Pigs Humans Indomethacin - pharmacology Lymphocyte Activation - drug effects Lymphokines - biosynthesis Male Rats |
| title | AUGMENTATION OF DRUG-INDUCED LYMPHOCYTE TRANSFORMATION BY INDOMETHACIN IN PATIENTS WITH DRUG-INDUCED ALLERGIC HEPATITIS |
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