Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after T H 2-biased immunization

Vaccine-associated enhanced respiratory disease (VAERD) is a severe complication for some respiratory infections. To investigate the potential for VAERD induction in coronavirus disease 2019 (COVID-19), we evaluate two vaccine leads utilizing a severe hamster infection model: a T helper type 1 (T 1)...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-08, Vol.40 (7), p.111214
Hauptverfasser:	Ebenig, Aileen, Muraleedharan, Samada, Kazmierski, Julia, Todt, Daniel, Auste, Arne, Anzaghe, Martina, Gömer, André, Postmus, Dylan, Gogesch, Patricia, Niles, Marc, Plesker, Roland, Miskey, Csaba, Gellhorn Serra, Michelle, Breithaupt, Angele, Hörner, Cindy, Kruip, Carina, Ehmann, Rosina, Ivics, Zoltan, Waibler, Zoe, Pfaender, Stephanie, Wyler, Emanuel, Landthaler, Markus, Kupke, Alexandra, Nouailles, Geraldine, Goffinet, Christine, Brown, Richard J P, Mühlebach, Michael D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral COVID-19 Cricetinae Cytokines - metabolism Immunization Lung - pathology Mice Mice, Inbred BALB C Th1 Cells Th2 Cells Vaccination Vaccines
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