Dust fall PM 2.5 -induced lung inflammation in rats is associated with hypermethylation of the IFN-γ gene promoter via the PI3K-Akt-DNMT3b pathway

Inflammation is one of the major adverse effects of fine particulate matter (PM ) on the lung system; however, its mechanisms remain unclear. Rats were exposed to different concentrations of PM to investigate the mechanism of short-term exposure-induced lung inflammation. The regulation of PI3K-Akt...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2022-10, Vol.95, p.103942
Hauptverfasser:	Bai, Jun, Wang, Hailan, Yang, Siyu, Lu, Ji, Li, Chenwen, Sun, Yaochuan, Huo, Tingting, Deng, Jianjun, Zhang, Qingbi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA DNA (Cytosine-5-)-Methyltransferases DNA Methyltransferase 3B Dust Interferon-gamma - genetics Interleukin-13 Interleukin-4 Interleukin-5 Lung Particulate Matter - toxicity Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Pneumonia Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats
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