TOLLIP-mediated autophagic degradation pathway links the VCP-TMEM63A-DERL1 signaling axis to triple-negative breast cancer progression

Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat due to the lack of effective targeted therapies. Transmembrane (TMEM) proteins represent attractive drug targets for cancer therapy, but biological functions of most members of the TMEM family remain unknown....

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Veröffentlicht in:	Autophagy 2023-03, Vol.19 (3), p.805-821
Hauptverfasser:	Zhang, Tai-Mei, Liao, Li, Yang, Shao-Ying, Huang, Min-Ying, Zhang, Yin-Ling, Deng, Ling, Hu, Shu-Yuan, Yang, Fan, Zhang, Fang-Lin, Shao, Zhi-Min, Li, Da-Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Regulatory Proteins - metabolism Autophagy Endoplasmic Reticulum-Associated Degradation Humans Intracellular Signaling Peptides and Proteins - metabolism Macroautophagic degradation Membrane Proteins - metabolism proteostasis Research Paper selective autophagy receptor Signal Transduction transmembrane protein Triple Negative Breast Neoplasms triple-negative breast cancer Valosin Containing Protein - metabolism
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