Deuterium isotope effect on denitrosation and demethylation of N-nitrosodimethylamine by rat liver microsomes

In an attempt to elucidate the molecular basis for the decrease in rat liver carcinogenicity and DNA-alkylating ability that accompanies deuteration of N-nitrosodimethylamine (NDMA), NDMA and its fully deuterated analogue ([2H6]NDMA) were incubated with acetone-induced rat liver microsomes. Rates fo...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1987-07, Vol.47 (13), p.3373-3377
Hauptverfasser:	WADE, D, YANG, C. S, METRAL, C. J, ROMAN, J. M, HRABIE, J. A, RIGGS, C. W, ANJO, T, KEEFER, L. K, MICO, B. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Cytochrome P-450 CYP2E1 Deuterium Dimethylnitrosamine - metabolism In Vitro Techniques Kinetics Mass Spectrometry Medical sciences Methylation Microsomes, Liver - metabolism Nitrates - metabolism Oxidoreductases, N-Demethylating - metabolism Rats Tumors
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