Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms
Tumor lysis syndrome (TLS) is an oncologic emergency characterized by the destruction of tumor cells leading to an influx of large amounts of uric acid, potassium, and phosphorus into systemic circulation. It most often occurs after the initiation of cytotoxic therapy in high-grade lymphomas and leu...
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| Veröffentlicht in: | Case Reports in Oncology 2022-01, Vol.15 (1), p.442-446 |
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| creator | Menakuru, Sasmith R. Priscu, Adelina Khan, Ibrahim Beirat, Amir |
| description | Tumor lysis syndrome (TLS) is an oncologic emergency characterized by the destruction of tumor cells leading to an influx of large amounts of uric acid, potassium, and phosphorus into systemic circulation. It most often occurs after the initiation of cytotoxic therapy in high-grade lymphomas and leukemias; however, rarely it may occur spontaneously. The authors report a case of spontaneous tumor lysis causing electrolyte abnormalities and acute kidney injury in a patient with subsequently diagnosed large chronic lymphocytic leukemia tumor burden. Spontaneous TLS can be the first presentation of underlying malignancy; therefore, physicians should be aware of the associated findings. |
| doi_str_mv | 10.1159/000524198 |
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Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6816-9262</orcidid></search><sort><creationdate>20220101</creationdate><title>Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms</title><author>Menakuru, Sasmith R. ; Priscu, Adelina ; Khan, Ibrahim ; Beirat, Amir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-335ff16504b4c398abd684c96c5ebb8bd04d5d47e2fcc83fca0c664a4b34a9493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>acute kidney injury</topic><topic>Cardiac arrhythmia</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Case studies</topic><topic>Chemotherapy</topic><topic>Chronic lymphocytic leukemia</topic><topic>Complications and side effects</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Creatinine</topic><topic>Diagnosis</topic><topic>Diagnosis, Differential</topic><topic>electrolyte abnormalities</topic><topic>Electrolytes</topic><topic>Hematology</topic><topic>Hemodialysis</topic><topic>Hyperkalemia</topic><topic>Hypocalcemia</topic><topic>Kidneys</topic><topic>Laboratories</topic><topic>large tumor burden</topic><topic>Leukemia</topic><topic>Lymphatic system</topic><topic>Lymphoma</topic><topic>Medical diagnosis</topic><topic>Metabolism</topic><topic>Risk factors</topic><topic>spontaneous tumor lysis syndrome</topic><topic>Steroids</topic><topic>Tomography</topic><topic>Tumor lysis syndrome</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Menakuru, Sasmith R.</creatorcontrib><creatorcontrib>Priscu, Adelina</creatorcontrib><creatorcontrib>Khan, Ibrahim</creatorcontrib><creatorcontrib>Beirat, Amir</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case Reports in Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Menakuru, Sasmith R.</au><au>Priscu, Adelina</au><au>Khan, Ibrahim</au><au>Beirat, Amir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms</atitle><jtitle>Case Reports in Oncology</jtitle><addtitle>Case Rep Oncol</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>15</volume><issue>1</issue><spage>442</spage><epage>446</epage><pages>442-446</pages><issn>1662-6575</issn><eissn>1662-6575</eissn><abstract>Tumor lysis syndrome (TLS) is an oncologic emergency characterized by the destruction of tumor cells leading to an influx of large amounts of uric acid, potassium, and phosphorus into systemic circulation. 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| subjects | acute kidney injury Cardiac arrhythmia Case Report Case reports Case studies Chemotherapy Chronic lymphocytic leukemia Complications and side effects Coronaviruses COVID-19 Creatinine Diagnosis Diagnosis, Differential electrolyte abnormalities Electrolytes Hematology Hemodialysis Hyperkalemia Hypocalcemia Kidneys Laboratories large tumor burden Leukemia Lymphatic system Lymphoma Medical diagnosis Metabolism Risk factors spontaneous tumor lysis syndrome Steroids Tomography Tumor lysis syndrome Uric acid |
| title | Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms |
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