Home sleep testing with peripheral arterial tonometry to assess outcome in upper airway stimulation
To determine whether home sleep testing with peripheral arterial tonometry (HST-PAT) can be used in upper airway stimulation (UAS) to evaluate therapy success. Data analysis from 50 consecutive UAS patients was performed. Baseline values were measured by polysomnography (PSG) and HST-PAT. Follow-up...
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| Veröffentlicht in: | Journal of clinical sleep medicine 2022-06 |
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| creator | Hinder, Dominik Schams, Simon C Knaus, Christoph Tschopp, Kurt |
| description | To determine whether home sleep testing with peripheral arterial tonometry (HST-PAT) can be used in upper airway stimulation (UAS) to evaluate therapy success.
Data analysis from 50 consecutive UAS patients was performed. Baseline values were measured by polysomnography (PSG) and HST-PAT. Follow-up was performed during and after titration (3- to 6-months) by PSG and HST-PAT and after 1 year by HST-PAT only. Primary outcome measures were reduction in apnea-hypopnea-index (AHI) and oxygen-desaturation-index (ODI). Additionally, an analysis of night-to-night variability (NNV) for HST-PAT was performed.
All 50 patients completed their post-titration visit (3- to 6-months) and 41 patients the 1-year follow up. In HST-PAT after 1-year, mean AHI (desaturation 3%) was reduced from 29.5±17.1 to 19.9±13.1 (p |
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Data analysis from 50 consecutive UAS patients was performed. Baseline values were measured by polysomnography (PSG) and HST-PAT. Follow-up was performed during and after titration (3- to 6-months) by PSG and HST-PAT and after 1 year by HST-PAT only. Primary outcome measures were reduction in apnea-hypopnea-index (AHI) and oxygen-desaturation-index (ODI). Additionally, an analysis of night-to-night variability (NNV) for HST-PAT was performed.
All 50 patients completed their post-titration visit (3- to 6-months) and 41 patients the 1-year follow up. In HST-PAT after 1-year, mean AHI (desaturation 3%) was reduced from 29.5±17.1 to 19.9±13.1 (p<0.01) and ODI (desaturation 4%) from 17.8±12.6 to 10.2±8.3 (p<0.01). Therapy adherence after 1-year was high (6.6 ± 1.9 hours per night) and led to improvement in daytime sleepiness, meaning a reduction in Epworth sleepiness scale from 12.8 ± 5.4 to 5.9 ± 4.0 (p < 0.01). Analysis of NNV showed similar AHI values between the two nights.
UAS was able to reduce AHI and ODI after 1-year, assessed by full-night efficacy studies with HST-PAT. Additionally, improvements in subjective outcome parameters were observed. The importance of publishing the scoring criteria is highlighted and whether data is based on full-night efficacy studies or a selected period of time from a sleep study. This is a prerequisite for comparing data with other trials in the emerging field of UAS.</description><identifier>EISSN: 1550-9397</identifier><identifier>PMID: 35689596</identifier><language>eng</language><publisher>United States</publisher><ispartof>Journal of clinical sleep medicine, 2022-06</ispartof><rights>2022 American Academy of Sleep Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35689596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hinder, Dominik</creatorcontrib><creatorcontrib>Schams, Simon C</creatorcontrib><creatorcontrib>Knaus, Christoph</creatorcontrib><creatorcontrib>Tschopp, Kurt</creatorcontrib><title>Home sleep testing with peripheral arterial tonometry to assess outcome in upper airway stimulation</title><title>Journal of clinical sleep medicine</title><addtitle>J Clin Sleep Med</addtitle><description>To determine whether home sleep testing with peripheral arterial tonometry (HST-PAT) can be used in upper airway stimulation (UAS) to evaluate therapy success.
Data analysis from 50 consecutive UAS patients was performed. Baseline values were measured by polysomnography (PSG) and HST-PAT. Follow-up was performed during and after titration (3- to 6-months) by PSG and HST-PAT and after 1 year by HST-PAT only. Primary outcome measures were reduction in apnea-hypopnea-index (AHI) and oxygen-desaturation-index (ODI). Additionally, an analysis of night-to-night variability (NNV) for HST-PAT was performed.
All 50 patients completed their post-titration visit (3- to 6-months) and 41 patients the 1-year follow up. In HST-PAT after 1-year, mean AHI (desaturation 3%) was reduced from 29.5±17.1 to 19.9±13.1 (p<0.01) and ODI (desaturation 4%) from 17.8±12.6 to 10.2±8.3 (p<0.01). Therapy adherence after 1-year was high (6.6 ± 1.9 hours per night) and led to improvement in daytime sleepiness, meaning a reduction in Epworth sleepiness scale from 12.8 ± 5.4 to 5.9 ± 4.0 (p < 0.01). Analysis of NNV showed similar AHI values between the two nights.
UAS was able to reduce AHI and ODI after 1-year, assessed by full-night efficacy studies with HST-PAT. Additionally, improvements in subjective outcome parameters were observed. The importance of publishing the scoring criteria is highlighted and whether data is based on full-night efficacy studies or a selected period of time from a sleep study. This is a prerequisite for comparing data with other trials in the emerging field of UAS.</description><issn>1550-9397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFjk0KwjAUhIMgtv5cQd4FCtWa1qxF6QHcl1ifNtImIS-h9PZG0LWrmYFvhpmxdMd5nolCVAlbEr3y_LDnFV-wpODlUXBRpqytzYBAPaIFj-SVfsKofAcWnbIdOtmDdD6GaLzRkfZuig4kERKBCb79TCgNwcYSSOVGOUGcGkIvvTJ6zeYP2RNuvrpi28v5eqozG24D3hvr1CDd1PxeFX-BN7gzRQE</recordid><startdate>20220611</startdate><enddate>20220611</enddate><creator>Hinder, Dominik</creator><creator>Schams, Simon C</creator><creator>Knaus, Christoph</creator><creator>Tschopp, Kurt</creator><scope>NPM</scope></search><sort><creationdate>20220611</creationdate><title>Home sleep testing with peripheral arterial tonometry to assess outcome in upper airway stimulation</title><author>Hinder, Dominik ; Schams, Simon C ; Knaus, Christoph ; Tschopp, Kurt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_356895963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hinder, Dominik</creatorcontrib><creatorcontrib>Schams, Simon C</creatorcontrib><creatorcontrib>Knaus, Christoph</creatorcontrib><creatorcontrib>Tschopp, Kurt</creatorcontrib><collection>PubMed</collection><jtitle>Journal of clinical sleep medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hinder, Dominik</au><au>Schams, Simon C</au><au>Knaus, Christoph</au><au>Tschopp, Kurt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Home sleep testing with peripheral arterial tonometry to assess outcome in upper airway stimulation</atitle><jtitle>Journal of clinical sleep medicine</jtitle><addtitle>J Clin Sleep Med</addtitle><date>2022-06-11</date><risdate>2022</risdate><eissn>1550-9397</eissn><abstract>To determine whether home sleep testing with peripheral arterial tonometry (HST-PAT) can be used in upper airway stimulation (UAS) to evaluate therapy success.
Data analysis from 50 consecutive UAS patients was performed. Baseline values were measured by polysomnography (PSG) and HST-PAT. Follow-up was performed during and after titration (3- to 6-months) by PSG and HST-PAT and after 1 year by HST-PAT only. Primary outcome measures were reduction in apnea-hypopnea-index (AHI) and oxygen-desaturation-index (ODI). Additionally, an analysis of night-to-night variability (NNV) for HST-PAT was performed.
All 50 patients completed their post-titration visit (3- to 6-months) and 41 patients the 1-year follow up. In HST-PAT after 1-year, mean AHI (desaturation 3%) was reduced from 29.5±17.1 to 19.9±13.1 (p<0.01) and ODI (desaturation 4%) from 17.8±12.6 to 10.2±8.3 (p<0.01). Therapy adherence after 1-year was high (6.6 ± 1.9 hours per night) and led to improvement in daytime sleepiness, meaning a reduction in Epworth sleepiness scale from 12.8 ± 5.4 to 5.9 ± 4.0 (p < 0.01). Analysis of NNV showed similar AHI values between the two nights.
UAS was able to reduce AHI and ODI after 1-year, assessed by full-night efficacy studies with HST-PAT. Additionally, improvements in subjective outcome parameters were observed. The importance of publishing the scoring criteria is highlighted and whether data is based on full-night efficacy studies or a selected period of time from a sleep study. This is a prerequisite for comparing data with other trials in the emerging field of UAS.</abstract><cop>United States</cop><pmid>35689596</pmid></addata></record> |
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| title | Home sleep testing with peripheral arterial tonometry to assess outcome in upper airway stimulation |
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