Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA 2 DS 2 -VA Scores among Patients with Atrial Fibrillation

Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA 2 DS 2 -VA Scores among Patients with Atrial Fibrillation

(1) Background: We hypothesized that female sex would have a differential impact on left atrial (LA) low-voltage areas (LVAs) according to CHA2DS2-VA scores. (2) Methods: This study included 553 patients who underwent radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). LVAs were de...

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Veröffentlicht in:Journal of clinical medicine 2022-05, Vol.11 (11)
Hauptverfasser: Kim, Do Young, Kim, Yun Gi, Choi, Ha Young, Choi, Yun Young, Boo, Ki Yung, Lee, Kwang-No, Roh, Seung-Young, Shim, Jaemin, Choi, Jong-Il, Kim, Young-Hoon
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container_issue 11
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container_title Journal of clinical medicine
container_volume 11
creator Kim, Do Young
Kim, Yun Gi
Choi, Ha Young
Choi, Yun Young
Boo, Ki Yung
Lee, Kwang-No
Roh, Seung-Young
Shim, Jaemin
Choi, Jong-Il
Kim, Young-Hoon
description (1) Background: We hypothesized that female sex would have a differential impact on left atrial (LA) low-voltage areas (LVAs) according to CHA2DS2-VA scores. (2) Methods: This study included 553 patients who underwent radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). LVAs were defined as regions with bipolar peak-to-peak voltages of
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(2) Methods: This study included 553 patients who underwent radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). LVAs were defined as regions with bipolar peak-to-peak voltages of &lt;0.5 mV. The proportion of LVAs was calculated by dividing the total LVA by the LA surface area. (3) Results: There was no sex-related difference in LA LVAs among patients with a CHA2DS2-VA scores ≤ 2. The proportion of LVAs was significantly higher in females among patients with CHA2DS2-VA scores of 3 or 4 (10.1 (4.7−15.1)% vs. 15.8 (9.2−32.1)%; p = 0.027). Female sex was significantly associated with extensive LVAs (LVA proportion ≥ 30%). Females had odd ratios of 27.82 (95% confidence interval (CI) 3.33−756.8, p = 0.01), and 1.53 (95% CI 0.81−2.83, p = 0.184) for extensive LAVs in patients with CHA2DS2-VA scores ≥ 3 and CHA2DS2-VA scores &lt; 3, respectively. In the multiple regression model, female patients with a CHA2DS2-VA ≥3 were significantly associated with a higher proportion of LVAs (β = 8.52, p = 0.039). (4) Conclusions: Female sex was significantly associated with extensive LVAs, particularly when their CHA2DS2-VA scores were ≥3. This result suggests that female sex has a differential effect on the extent of LVAs based on the presence of additional risk factors.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11113111</identifier><identifier>PMID: 35683498</identifier><language>eng</language><publisher>Switzerland</publisher><ispartof>Journal of clinical medicine, 2022-05, Vol.11 (11)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-0854-9079 ; 0000-0002-7430-415X ; 0000-0001-6617-508X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35683498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Do Young</creatorcontrib><creatorcontrib>Kim, Yun Gi</creatorcontrib><creatorcontrib>Choi, Ha Young</creatorcontrib><creatorcontrib>Choi, Yun Young</creatorcontrib><creatorcontrib>Boo, Ki Yung</creatorcontrib><creatorcontrib>Lee, Kwang-No</creatorcontrib><creatorcontrib>Roh, Seung-Young</creatorcontrib><creatorcontrib>Shim, Jaemin</creatorcontrib><creatorcontrib>Choi, Jong-Il</creatorcontrib><creatorcontrib>Kim, Young-Hoon</creatorcontrib><title>Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA 2 DS 2 -VA Scores among Patients with Atrial Fibrillation</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>(1) Background: We hypothesized that female sex would have a differential impact on left atrial (LA) low-voltage areas (LVAs) according to CHA2DS2-VA scores. (2) Methods: This study included 553 patients who underwent radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). LVAs were defined as regions with bipolar peak-to-peak voltages of &lt;0.5 mV. The proportion of LVAs was calculated by dividing the total LVA by the LA surface area. (3) Results: There was no sex-related difference in LA LVAs among patients with a CHA2DS2-VA scores ≤ 2. The proportion of LVAs was significantly higher in females among patients with CHA2DS2-VA scores of 3 or 4 (10.1 (4.7−15.1)% vs. 15.8 (9.2−32.1)%; p = 0.027). Female sex was significantly associated with extensive LVAs (LVA proportion ≥ 30%). Females had odd ratios of 27.82 (95% confidence interval (CI) 3.33−756.8, p = 0.01), and 1.53 (95% CI 0.81−2.83, p = 0.184) for extensive LAVs in patients with CHA2DS2-VA scores ≥ 3 and CHA2DS2-VA scores &lt; 3, respectively. In the multiple regression model, female patients with a CHA2DS2-VA ≥3 were significantly associated with a higher proportion of LVAs (β = 8.52, p = 0.039). (4) Conclusions: Female sex was significantly associated with extensive LVAs, particularly when their CHA2DS2-VA scores were ≥3. 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(2) Methods: This study included 553 patients who underwent radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). LVAs were defined as regions with bipolar peak-to-peak voltages of &lt;0.5 mV. The proportion of LVAs was calculated by dividing the total LVA by the LA surface area. (3) Results: There was no sex-related difference in LA LVAs among patients with a CHA2DS2-VA scores ≤ 2. The proportion of LVAs was significantly higher in females among patients with CHA2DS2-VA scores of 3 or 4 (10.1 (4.7−15.1)% vs. 15.8 (9.2−32.1)%; p = 0.027). Female sex was significantly associated with extensive LVAs (LVA proportion ≥ 30%). Females had odd ratios of 27.82 (95% confidence interval (CI) 3.33−756.8, p = 0.01), and 1.53 (95% CI 0.81−2.83, p = 0.184) for extensive LAVs in patients with CHA2DS2-VA scores ≥ 3 and CHA2DS2-VA scores &lt; 3, respectively. In the multiple regression model, female patients with a CHA2DS2-VA ≥3 were significantly associated with a higher proportion of LVAs (β = 8.52, p = 0.039). (4) Conclusions: Female sex was significantly associated with extensive LVAs, particularly when their CHA2DS2-VA scores were ≥3. This result suggests that female sex has a differential effect on the extent of LVAs based on the presence of additional risk factors.</abstract><cop>Switzerland</cop><pmid>35683498</pmid><doi>10.3390/jcm11113111</doi><orcidid>https://orcid.org/0000-0002-0854-9079</orcidid><orcidid>https://orcid.org/0000-0002-7430-415X</orcidid><orcidid>https://orcid.org/0000-0001-6617-508X</orcidid></addata></record>
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title Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA 2 DS 2 -VA Scores among Patients with Atrial Fibrillation
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