Fatty acid-based polymeric micelles to ameliorate amyloidogenic disorders

To develop anti-amyloidogenic inhibitors for ameliorating the treatment of diabetes, herein, we have synthesised amphiphilic block copolymers with side-chain fatty acid (FA) moieties via reversible addition fragmentation chain-transfer (RAFT) polymerization. We addressed the unexplored role of FA pe...

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Veröffentlicht in:	Biomaterials science 2022-06, Vol.1 (13), p.3466-3479
Hauptverfasser:	Bera, Avisek, Mukhopadhyay, Debangana, Goswami, Kalyan, Ghosh, Pooja, De, Rumi, De, Priyadarsi
Format:	Artikel
Sprache:	eng
Schlagworte:	Addition polymerization Block copolymers Chemical synthesis Dichroism Fatty acids Fibrillation Hydrophobicity Inhibitors Insulin Micelles Stearic acid Toxicity
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