Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits Na V 1.8 via Interactions With the DI Voltage Sensor and DII Pore Module

Voltage-gated sodium channel Na 1.8 regulates transmission of pain signals to the brain. While Na 1.8 has the potential to serve as a drug target, the molecular mechanisms that shape Na 1.8 gating are not completely understood, particularly mechanisms that couple activation to inactivation. Interact...

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Veröffentlicht in:	Frontiers in pharmacology 2022, Vol.13, p.846992
Hauptverfasser:	George, Kiran, Lopez-Mateos, Diego, Abd El-Aziz, Tarek Mohamed, Xiao, Yucheng, Kline, Jake, Bao, Hong, Raza, Syed, Stockand, James D, Cummins, Theodore R, Fornelli, Luca, Rowe, Matthew P, Yarov-Yarovoy, Vladimir, Rowe, Ashlee H
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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