HDL-Cholesterol and Incident Type 2 Diabetes Mellitus Among African Americans: The Jackson Heart Study

HDL-Cholesterol and Incident Type 2 Diabetes Mellitus Among African Americans: The Jackson Heart Study

Accruing evidence suggest an association between high-density lipoprotein- cholesterol (HDL-C) and incident diabetes. However, there is a paucity of data on the link between HDL-C and diabetes, especially among African Americans. To assess the association of HDL-C and its fractions with incident typ...

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Veröffentlicht in:Diabetic medicine 2022-05, p.e14895
Hauptverfasser: Agoons, Dayawa D, Musani, Solomon K, Correa, Adolfo, Golden, Sherita H, Bertoni, Alain G, Echouffo-Tcheugui, Justin B
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container_start_page e14895
container_title Diabetic medicine
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creator Agoons, Dayawa D
Musani, Solomon K
Correa, Adolfo
Golden, Sherita H
Bertoni, Alain G
Echouffo-Tcheugui, Justin B
description Accruing evidence suggest an association between high-density lipoprotein- cholesterol (HDL-C) and incident diabetes. However, there is a paucity of data on the link between HDL-C and diabetes, especially among African Americans. To assess the association of HDL-C and its fractions with incident type 2 diabetes among African Americans. We included Jackson Heart Study participants who attended visit 1 (2001-2004), were free from diabetes, and were not treated with lipid-modifying medications. Incident diabetes was assessed at two subsequent 4-yearly visits (2 and 3). We cross-sectionally assessed the association of HDL-C and insulin resistance using multivariable linear models. We prospectively assessed the association of HDL-C and its fractions with incident diabetes using multivariable Cox regression models. Among 2,829 participants (mean age: 51.9 ±12.4 years, 63.9% female), 487 individuals (17%) developed new-onset diabetes, over a median follow-up of 8 years. In adjusted models, a higher HDL-C concentration was associated with a lower odds of insulin resistance (OR per SD increment: OR 0.56 [95% CI 0.50-0.63], P
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However, there is a paucity of data on the link between HDL-C and diabetes, especially among African Americans. To assess the association of HDL-C and its fractions with incident type 2 diabetes among African Americans. We included Jackson Heart Study participants who attended visit 1 (2001-2004), were free from diabetes, and were not treated with lipid-modifying medications. Incident diabetes was assessed at two subsequent 4-yearly visits (2 and 3). We cross-sectionally assessed the association of HDL-C and insulin resistance using multivariable linear models. We prospectively assessed the association of HDL-C and its fractions with incident diabetes using multivariable Cox regression models. Among 2,829 participants (mean age: 51.9 ±12.4 years, 63.9% female), 487 individuals (17%) developed new-onset diabetes, over a median follow-up of 8 years. In adjusted models, a higher HDL-C concentration was associated with a lower odds of insulin resistance (OR per SD increment: OR 0.56 [95% CI 0.50-0.63], P&lt;0.001). In adjusted models, a higher HDL-C concentration was associated with a lower risk of diabetes (HR per SD increment: 0.78 [95% CI 0.71, 0.87], P&lt;0.001; HR for highest vs. the lowest tertile of HDL-C was 0.56 [95% CI: 0.44, 0.71], P&lt;0.001). In a sample of African American adults not on any lipid-modifying therapy, high HDL-C concentrations were inversely associated with the risk of new-onset diabetes. These findings suggest a strong link between HDL-C metabolism and glucose regulation.</description><identifier>EISSN: 1464-5491</identifier><identifier>PMID: 35639386</identifier><language>eng</language><publisher>England</publisher><ispartof>Diabetic medicine, 2022-05, p.e14895</ispartof><rights>This article is protected by copyright. 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