Natural History of Mitral Annulus Calcification and Calcific Mitral Valve Disease
The natural history of mitral annular calcification (MAC) and risk for developing calcific mitral valve disease (CMVD) has been poorly defined. We sought to evaluate the progression rate of MAC and of the development of CMVD. Patients with MAC and paired echocardiograms at least one year apart betwe...
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| Veröffentlicht in: | Journal of the American Society of Echocardiography 2022-05 |
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| container_title | Journal of the American Society of Echocardiography |
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| creator | Willner, Nadav Burwash, Ian G Beauchesne, Luc Chan, Vince Vulesevic, Branka Ascah, Kathy Coutinho, Thias Promislow, Steve Stadnick, Ellamae Chan, Kwan L Mesana, Thierry Messika-Zeitoun, David |
| description | The natural history of mitral annular calcification (MAC) and risk for developing calcific mitral valve disease (CMVD) has been poorly defined. We sought to evaluate the progression rate of MAC and of the development of CMVD.
Patients with MAC and paired echocardiograms at least one year apart between 2005 and 2019 were included. Progression rates from mild/moderate to severe MAC and to CMVD (defined as severe MAC and significant mitral stenosis and/or regurgitation) were assessed, along with potential association with sex.
A total of 11,605 patients (73±10years, 51%male) with MAC (78% mild, 17% moderate, 5% severe) were included and had a follow up echocardiogram at 4.2±2.7years. In patients with mild/moderate MAC, 33% presented with severe MAC at 10 years. The rate of severe MAC was higher in females than in males (41% vs. 24%, P |
| doi_str_mv | 10.1016/j.echo.2022.05.007 |
| format | Article |
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Patients with MAC and paired echocardiograms at least one year apart between 2005 and 2019 were included. Progression rates from mild/moderate to severe MAC and to CMVD (defined as severe MAC and significant mitral stenosis and/or regurgitation) were assessed, along with potential association with sex.
A total of 11,605 patients (73±10years, 51%male) with MAC (78% mild, 17% moderate, 5% severe) were included and had a follow up echocardiogram at 4.2±2.7years. In patients with mild/moderate MAC, 33% presented with severe MAC at 10 years. The rate of severe MAC was higher in females than in males (41% vs. 24%, P<0.001, HR=1.3, P<0.001) and in patients with moderate vs. mild MAC (71% vs. 22%, P<0.001, HR=6.1, P<0.001). At 10 years 10% presented with CMVD (4%, 23% and 60% in patients with mild, moderate, and severe MAC respectively) and was predicted by female sex (15% vs. 5%, P<0.0001), even after adjustment for MAC severity (HR=1.9, P<0.001).
In this large cohort of patients with MAC, progression to severe MAC was common and frequently results in CMVD. Female sex was associated with higher progression rates. MAC and CMVD are expected to dramatically increase as the population ages highlighting the importance of a better understanding of the pathophysiology of MAC in order to develop effective preventive medical therapies.]]></description><identifier>EISSN: 1097-6795</identifier><identifier>DOI: 10.1016/j.echo.2022.05.007</identifier><identifier>PMID: 35618253</identifier><language>eng</language><publisher>United States</publisher><ispartof>Journal of the American Society of Echocardiography, 2022-05</ispartof><rights>Copyright © 2022 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35618253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Willner, Nadav</creatorcontrib><creatorcontrib>Burwash, Ian G</creatorcontrib><creatorcontrib>Beauchesne, Luc</creatorcontrib><creatorcontrib>Chan, Vince</creatorcontrib><creatorcontrib>Vulesevic, Branka</creatorcontrib><creatorcontrib>Ascah, Kathy</creatorcontrib><creatorcontrib>Coutinho, Thias</creatorcontrib><creatorcontrib>Promislow, Steve</creatorcontrib><creatorcontrib>Stadnick, Ellamae</creatorcontrib><creatorcontrib>Chan, Kwan L</creatorcontrib><creatorcontrib>Mesana, Thierry</creatorcontrib><creatorcontrib>Messika-Zeitoun, David</creatorcontrib><title>Natural History of Mitral Annulus Calcification and Calcific Mitral Valve Disease</title><title>Journal of the American Society of Echocardiography</title><addtitle>J Am Soc Echocardiogr</addtitle><description><![CDATA[The natural history of mitral annular calcification (MAC) and risk for developing calcific mitral valve disease (CMVD) has been poorly defined. We sought to evaluate the progression rate of MAC and of the development of CMVD.
Patients with MAC and paired echocardiograms at least one year apart between 2005 and 2019 were included. Progression rates from mild/moderate to severe MAC and to CMVD (defined as severe MAC and significant mitral stenosis and/or regurgitation) were assessed, along with potential association with sex.
A total of 11,605 patients (73±10years, 51%male) with MAC (78% mild, 17% moderate, 5% severe) were included and had a follow up echocardiogram at 4.2±2.7years. In patients with mild/moderate MAC, 33% presented with severe MAC at 10 years. The rate of severe MAC was higher in females than in males (41% vs. 24%, P<0.001, HR=1.3, P<0.001) and in patients with moderate vs. mild MAC (71% vs. 22%, P<0.001, HR=6.1, P<0.001). At 10 years 10% presented with CMVD (4%, 23% and 60% in patients with mild, moderate, and severe MAC respectively) and was predicted by female sex (15% vs. 5%, P<0.0001), even after adjustment for MAC severity (HR=1.9, P<0.001).
In this large cohort of patients with MAC, progression to severe MAC was common and frequently results in CMVD. Female sex was associated with higher progression rates. MAC and CMVD are expected to dramatically increase as the population ages highlighting the importance of a better understanding of the pathophysiology of MAC in order to develop effective preventive medical therapies.]]></description><issn>1097-6795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFjssKgkAUQIcg0h4_0CLmB5zuKONjGVa0KQiirdx0pJHxgaOBfx9Btm114HAWh5A1B8aB-9uCyfRZMxdcl4FgAMGE2ByiwPGDSFhkbkwBACIEmBHLEz4PXeHZ5HrBrm9R05MyXd0OtM7pWXUfs6uqXveGxqhTlasUO1VXFKvsZ8byjvol6V4ZiUYuyTRHbeTqywXZHA-3-OQ0_aOUWdK0qsR2SMYH72_wBgQbQmw</recordid><startdate>20220523</startdate><enddate>20220523</enddate><creator>Willner, Nadav</creator><creator>Burwash, Ian G</creator><creator>Beauchesne, Luc</creator><creator>Chan, Vince</creator><creator>Vulesevic, Branka</creator><creator>Ascah, Kathy</creator><creator>Coutinho, Thias</creator><creator>Promislow, Steve</creator><creator>Stadnick, Ellamae</creator><creator>Chan, Kwan L</creator><creator>Mesana, Thierry</creator><creator>Messika-Zeitoun, David</creator><scope>NPM</scope></search><sort><creationdate>20220523</creationdate><title>Natural History of Mitral Annulus Calcification and Calcific Mitral Valve Disease</title><author>Willner, Nadav ; Burwash, Ian G ; Beauchesne, Luc ; Chan, Vince ; Vulesevic, Branka ; Ascah, Kathy ; Coutinho, Thias ; Promislow, Steve ; Stadnick, Ellamae ; Chan, Kwan L ; Mesana, Thierry ; Messika-Zeitoun, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_356182533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Willner, Nadav</creatorcontrib><creatorcontrib>Burwash, Ian G</creatorcontrib><creatorcontrib>Beauchesne, Luc</creatorcontrib><creatorcontrib>Chan, Vince</creatorcontrib><creatorcontrib>Vulesevic, Branka</creatorcontrib><creatorcontrib>Ascah, Kathy</creatorcontrib><creatorcontrib>Coutinho, Thias</creatorcontrib><creatorcontrib>Promislow, Steve</creatorcontrib><creatorcontrib>Stadnick, Ellamae</creatorcontrib><creatorcontrib>Chan, Kwan L</creatorcontrib><creatorcontrib>Mesana, Thierry</creatorcontrib><creatorcontrib>Messika-Zeitoun, David</creatorcontrib><collection>PubMed</collection><jtitle>Journal of the American Society of Echocardiography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Willner, Nadav</au><au>Burwash, Ian G</au><au>Beauchesne, Luc</au><au>Chan, Vince</au><au>Vulesevic, Branka</au><au>Ascah, Kathy</au><au>Coutinho, Thias</au><au>Promislow, Steve</au><au>Stadnick, Ellamae</au><au>Chan, Kwan L</au><au>Mesana, Thierry</au><au>Messika-Zeitoun, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural History of Mitral Annulus Calcification and Calcific Mitral Valve Disease</atitle><jtitle>Journal of the American Society of Echocardiography</jtitle><addtitle>J Am Soc Echocardiogr</addtitle><date>2022-05-23</date><risdate>2022</risdate><eissn>1097-6795</eissn><abstract><![CDATA[The natural history of mitral annular calcification (MAC) and risk for developing calcific mitral valve disease (CMVD) has been poorly defined. We sought to evaluate the progression rate of MAC and of the development of CMVD.
Patients with MAC and paired echocardiograms at least one year apart between 2005 and 2019 were included. Progression rates from mild/moderate to severe MAC and to CMVD (defined as severe MAC and significant mitral stenosis and/or regurgitation) were assessed, along with potential association with sex.
A total of 11,605 patients (73±10years, 51%male) with MAC (78% mild, 17% moderate, 5% severe) were included and had a follow up echocardiogram at 4.2±2.7years. In patients with mild/moderate MAC, 33% presented with severe MAC at 10 years. The rate of severe MAC was higher in females than in males (41% vs. 24%, P<0.001, HR=1.3, P<0.001) and in patients with moderate vs. mild MAC (71% vs. 22%, P<0.001, HR=6.1, P<0.001). At 10 years 10% presented with CMVD (4%, 23% and 60% in patients with mild, moderate, and severe MAC respectively) and was predicted by female sex (15% vs. 5%, P<0.0001), even after adjustment for MAC severity (HR=1.9, P<0.001).
In this large cohort of patients with MAC, progression to severe MAC was common and frequently results in CMVD. Female sex was associated with higher progression rates. MAC and CMVD are expected to dramatically increase as the population ages highlighting the importance of a better understanding of the pathophysiology of MAC in order to develop effective preventive medical therapies.]]></abstract><cop>United States</cop><pmid>35618253</pmid><doi>10.1016/j.echo.2022.05.007</doi></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present) |
| title | Natural History of Mitral Annulus Calcification and Calcific Mitral Valve Disease |
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