Impact of protein conformational diversity on AlphaFold predictions

After the outstanding breakthrough of AlphaFold in predicting protein 3D models, new questions appeared and remain unanswered. The ensemble nature of proteins, for example, challenges the structural prediction methods because the models should represent a set of conformers instead of single structur...

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Veröffentlicht in:	Bioinformatics (Oxford, England) England), 2022-05, Vol.38 (10), p.2742
Hauptverfasser:	Saldaño, Tadeo, Escobedo, Nahuel, Marchetti, Julia, Zea, Diego Javier, Mac Donagh, Juan, Velez Rueda, Ana Julia, Gonik, Eduardo, García Melani, Agustina, Novomisky Nechcoff, Julieta, Salas, Martín N, Peters, Tomás, Demitroff, Nicolás, Fernandez Alberti, Sebastian, Palopoli, Nicolas, Fornasari, Maria Silvina, Parisi, Gustavo
Format:	Artikel
Sprache:	eng
Schlagworte:	Protein Binding Protein Conformation Proteins - chemistry
Online-Zugang:	Volltext
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