Potential role of BAY11-7082, a NF-κB blocker inhibiting experimental autoimmune encephalomyelitis in C57BL/6J mice via declining NLRP3 inflammasomes

Multiple sclerosis (MS) is an inflammatory autoimmune demyelinating disease of the central nervous system. NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is implicated in the pathogenesis of MS and its animal model, experimental autoimmune encephalomyelitis (EAE). However, the exac...

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Veröffentlicht in:	Clinical and experimental immunology 2022-05, Vol.207 (3), p.378
Hauptverfasser:	Lang, Yue, Chu, Fengna, Liu, Lingling, Zheng, Chao, Li, Chunrong, Shen, Donghui, Liu, Shan, Zhang, Weiguanliu, Cui, Li, Zhu, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Encephalomyelitis, Autoimmune, Experimental Inflammasomes - metabolism Mice Mice, Inbred C57BL Multiple Sclerosis NF-kappa B - metabolism Nitriles NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Sulfones
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