Electrophilic alkylation of arenes with 5-bromopyrimidine en route to 4-aryl-5-alkynylpyrimidines

A new synthetic protocol for preparation of medicinally important 4-aryl-5-alkynylpyrimidines is described. The featured approach involves a sequence of chemo- and regioselective Brønsted acid-catalyzed electrophilic alkylation of arenes with 5-bromopyrimidine, followed by oxidative re-aromatization...

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Veröffentlicht in:	RSC advances 2020-03, Vol.1 (17), p.1315-1321
Hauptverfasser:	Shcherbakov, Stanislav S, Magometov, Artyom Yu, Shcherbakova, Viktoriia Yu, Aksenov, Alexander V, Domenyuk, Dmitriy A, Zelensky, Vladimir A, Rubin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Aromatic compounds Chemical reactions Chemistry Cross coupling Crystallography Game theory Palladium
Online-Zugang:	Volltext
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