Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-]pyrimidines as potential anti-chikungunya agents
Convergent and convenient regioselective synthesis of novel thiazolo[2,3- a ]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals...
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| Veröffentlicht in: | RSC advances 2020-01, Vol.1 (9), p.5191-5195 |
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| container_title | RSC advances |
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| creator | Fares, Mohamed McCosker, Patrick M Alsherbiny, Muhammad A Willis, Anthony C Clark, Timothy Neyts, Johan Jochmans, Dirk Keller, Paul A |
| description | Convergent and convenient regioselective synthesis of novel thiazolo[2,3-
a
]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the
Z
configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.
Convergent and convenient regioselective synthesis of novel thiazolo[2,3-
a
]pyrimidines was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. |
| doi_str_mv | 10.1039/d0ra00257g |
| format | Article |
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Z
configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.
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Z
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Convergent and convenient regioselective synthesis of novel thiazolo[2,3-
a
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a
]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the
Z
configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.
Convergent and convenient regioselective synthesis of novel thiazolo[2,3-
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acetic acid Aldehydes Chemistry Chikungunya virus Convergence Crystallography Pyrimidines Regioselectivity Sodium acetate Synthesis |
| title | Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-]pyrimidines as potential anti-chikungunya agents |
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